node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSMD1 | UBB | ENSP00000309474 | ENSP00000304697 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | ubiquitin B | 0.973 |
PSMD1 | UBC | ENSP00000309474 | ENSP00000344818 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | ubiquitin C | 0.999 |
PSMD1 | USP14 | ENSP00000309474 | ENSP00000261601 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase); Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stres [...] | 0.999 |
PSMD1 | USP5 | ENSP00000309474 | ENSP00000229268 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | ubiquitin specific peptidase 5 (isopeptidase T); Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored ’Lys-48’-linked polyubiquitin disassembly. Binds linear and ’Lys- 63’-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition | 0.709 |
PSMD1 | VCP | ENSP00000309474 | ENSP00000351777 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | valosin containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the e [...] | 0.522 |
UBB | PSMD1 | ENSP00000304697 | ENSP00000309474 | ubiquitin B | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.973 |
UBB | UBC | ENSP00000304697 | ENSP00000344818 | ubiquitin B | ubiquitin C | 0.999 |
UBB | UCHL1 | ENSP00000304697 | ENSP00000284440 | ubiquitin B | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity | 0.579 |
UBB | USP1 | ENSP00000304697 | ENSP00000343526 | ubiquitin B | ubiquitin specific peptidase 1; Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity | 0.962 |
UBB | USP14 | ENSP00000304697 | ENSP00000261601 | ubiquitin B | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase); Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stres [...] | 0.911 |
UBB | USP43 | ENSP00000304697 | ENSP00000285199 | ubiquitin B | ubiquitin specific peptidase 43; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity) | 0.466 |
UBB | USP5 | ENSP00000304697 | ENSP00000229268 | ubiquitin B | ubiquitin specific peptidase 5 (isopeptidase T); Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored ’Lys-48’-linked polyubiquitin disassembly. Binds linear and ’Lys- 63’-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition | 0.701 |
UBB | USP7 | ENSP00000304697 | ENSP00000343535 | ubiquitin B | ubiquitin specific peptidase 7 (herpes virus-associated); Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53- dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen pero [...] | 0.917 |
UBB | VCP | ENSP00000304697 | ENSP00000351777 | ubiquitin B | valosin containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the e [...] | 0.819 |
UBC | PSMD1 | ENSP00000344818 | ENSP00000309474 | ubiquitin C | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.999 |
UBC | UBB | ENSP00000344818 | ENSP00000304697 | ubiquitin C | ubiquitin B | 0.999 |
UBC | UCHL1 | ENSP00000344818 | ENSP00000284440 | ubiquitin C | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity | 0.999 |
UBC | USP1 | ENSP00000344818 | ENSP00000343526 | ubiquitin C | ubiquitin specific peptidase 1; Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity | 0.998 |
UBC | USP14 | ENSP00000344818 | ENSP00000261601 | ubiquitin C | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase); Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stres [...] | 0.999 |
UBC | USP43 | ENSP00000344818 | ENSP00000285199 | ubiquitin C | ubiquitin specific peptidase 43; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity) | 0.466 |