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STRINGSTRING
DUOX2 DUOX2 DUOXA2 DUOXA2 FOXI1 FOXI1 SLC26A4 SLC26A4 SLC5A5 SLC5A5 TPO TPO TG TG IYD IYD NVL NVL TDG TDG BLVRB BLVRB
"IYD" - iodotyrosine deiodinase in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Cooccurence
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[Homology]
Score
IYDiodotyrosine deiodinase (293 aa)    
Predicted Functional Partners:
TPO
thyroid peroxidase (933 aa)
          score_image score_image   0.958
SLC5A5
solute carrier family 5 (sodium iodide symporter), member 5; Mediates iodide uptake in the thyroid gland (643 aa)
            score_image   0.776
DUOXA2
dual oxidase maturation factor 2; Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis (320 aa)
            score_image   0.746
DUOX2
dual oxidase 2; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain (1548 aa)
            score_image   0.741
BLVRB
biliverdin reductase B (flavin reductase (NADPH)); Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin (206 aa)
            score_image   0.685
FOXI1
forkhead box I1; Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity) (378 aa)
            score_image   0.680
NVL
nuclear VCP-like (856 aa)
            score_image   0.623
SLC26A4
solute carrier family 26, member 4; Sodium-independent transporter of chloride and iodide (780 aa)
            score_image   0.608
TDG
thymine-DNA glycosylase; DNA glycosylase that plays a key role in active DNA demethylation- specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5- hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase t [...] (410 aa)
            score_image   0.580
TG
thyroglobulin (2768 aa)
            score_image   0.565
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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