node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD16 | NGLY1 | ENSP00000369434 | ENSP00000280700 | ankyrin repeat domain 16 | N-glycanase 1; Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for sub [...] | 0.634 |
ANKRD16 | NSMCE4A | ENSP00000369434 | ENSP00000358019 | ankyrin repeat domain 16 | non-SMC element 4 homolog A (S. cerevisiae); Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Is involved [...] | 0.640 |
ANKRD16 | TMEM14C | ENSP00000369434 | ENSP00000229563 | ankyrin repeat domain 16 | transmembrane protein 14C; Required for normal heme biosynthesis (By similarity) | 0.618 |
ISCA1 | SLC25A39 | ENSP00000365159 | ENSP00000366299 | iron-sulfur cluster assembly 1 homolog (S. cerevisiae); Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly | solute carrier family 25, member 39; Required for normal heme biosynthesis (By similarity) | 0.496 |
ISCA1 | TMEM14C | ENSP00000365159 | ENSP00000229563 | iron-sulfur cluster assembly 1 homolog (S. cerevisiae); Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly | transmembrane protein 14C; Required for normal heme biosynthesis (By similarity) | 0.609 |
NDUFS3 | TMEM14C | ENSP00000263774 | ENSP00000229563 | NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase); Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) | transmembrane protein 14C; Required for normal heme biosynthesis (By similarity) | 0.644 |
NGLY1 | ANKRD16 | ENSP00000280700 | ENSP00000369434 | N-glycanase 1; Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for sub [...] | ankyrin repeat domain 16 | 0.634 |
NGLY1 | NSMCE4A | ENSP00000280700 | ENSP00000358019 | N-glycanase 1; Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for sub [...] | non-SMC element 4 homolog A (S. cerevisiae); Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Is involved [...] | 0.621 |
NGLY1 | TMEM14C | ENSP00000280700 | ENSP00000229563 | N-glycanase 1; Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for sub [...] | transmembrane protein 14C; Required for normal heme biosynthesis (By similarity) | 0.594 |
NSMCE4A | ANKRD16 | ENSP00000358019 | ENSP00000369434 | non-SMC element 4 homolog A (S. cerevisiae); Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Is involved [...] | ankyrin repeat domain 16 | 0.640 |
NSMCE4A | NGLY1 | ENSP00000358019 | ENSP00000280700 | non-SMC element 4 homolog A (S. cerevisiae); Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Is involved [...] | N-glycanase 1; Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for sub [...] | 0.621 |
NSMCE4A | TMEM14C | ENSP00000358019 | ENSP00000229563 | non-SMC element 4 homolog A (S. cerevisiae); Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Is involved [...] | transmembrane protein 14C; Required for normal heme biosynthesis (By similarity) | 0.624 |
SFXN1 | TMEM14C | ENSP00000316905 | ENSP00000229563 | sideroflexin 1; Might be involved in the transport of a component required for iron utilization into or out of the mitochondria | transmembrane protein 14C; Required for normal heme biosynthesis (By similarity) | 0.644 |
SLC22A4 | TMEM14C | ENSP00000200652 | ENSP00000229563 | solute carrier family 22 (organic cation/ergothioneine transporter), member 4; Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET) | transmembrane protein 14C; Required for normal heme biosynthesis (By similarity) | 0.578 |
SLC22A5 | TMEM14C | ENSP00000245407 | ENSP00000229563 | solute carrier family 22 (organic cation/carnitine transporter), member 5; Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3 | transmembrane protein 14C; Required for normal heme biosynthesis (By similarity) | 0.567 |
SLC25A39 | ISCA1 | ENSP00000366299 | ENSP00000365159 | solute carrier family 25, member 39; Required for normal heme biosynthesis (By similarity) | iron-sulfur cluster assembly 1 homolog (S. cerevisiae); Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly | 0.496 |
SLC25A39 | TMEM14C | ENSP00000366299 | ENSP00000229563 | solute carrier family 25, member 39; Required for normal heme biosynthesis (By similarity) | transmembrane protein 14C; Required for normal heme biosynthesis (By similarity) | 0.575 |
SPCS2 | TMEM14C | ENSP00000263672 | ENSP00000229563 | signal peptidase complex subunit 2 homolog (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | transmembrane protein 14C; Required for normal heme biosynthesis (By similarity) | 0.644 |
TMEM14C | ANKRD16 | ENSP00000229563 | ENSP00000369434 | transmembrane protein 14C; Required for normal heme biosynthesis (By similarity) | ankyrin repeat domain 16 | 0.618 |
TMEM14C | ISCA1 | ENSP00000229563 | ENSP00000365159 | transmembrane protein 14C; Required for normal heme biosynthesis (By similarity) | iron-sulfur cluster assembly 1 homolog (S. cerevisiae); Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly | 0.609 |