| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AIPL1 | CRB1 | ENSP00000370521 | ENSP00000356370 | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | crumbs homolog 1 (Drosophila) | 0.824 |
| AIPL1 | PDE6A | ENSP00000370521 | ENSP00000255266 | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | phosphodiesterase 6A, cGMP-specific, rod, alpha; This protein participates in processes of transmission and amplification of the visual signal | 0.511 |
| AIPL1 | PDE6B | ENSP00000370521 | ENSP00000420295 | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme | 0.472 |
| AIPL1 | PDE6C | ENSP00000370521 | ENSP00000360502 | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | phosphodiesterase 6C, cGMP-specific, cone, alpha prime | 0.426 |
| AIPL1 | RDH12 | ENSP00000370521 | ENSP00000267502 | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | retinol dehydrogenase 12 (all-trans/9-cis/11-cis); Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments | 0.794 |
| AIPL1 | RPE65 | ENSP00000370521 | ENSP00000262340 | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | retinal pigment epithelium-specific protein 65kDa; Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis- retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of th [...] | 0.815 |
| AIPL1 | TULP1 | ENSP00000370521 | ENSP00000229771 | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | tubby like protein 1; Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro) [...] | 0.763 |
| AXL | TULP1 | ENSP00000301178 | ENSP00000229771 | AXL receptor tyrosine kinase; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AX [...] | tubby like protein 1; Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro) [...] | 0.817 |
| CRB1 | AIPL1 | ENSP00000356370 | ENSP00000370521 | crumbs homolog 1 (Drosophila) | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | 0.824 |
| CRB1 | PDE6A | ENSP00000356370 | ENSP00000255266 | crumbs homolog 1 (Drosophila) | phosphodiesterase 6A, cGMP-specific, rod, alpha; This protein participates in processes of transmission and amplification of the visual signal | 0.507 |
| CRB1 | PDE6B | ENSP00000356370 | ENSP00000420295 | crumbs homolog 1 (Drosophila) | phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme | 0.499 |
| CRB1 | RDH12 | ENSP00000356370 | ENSP00000267502 | crumbs homolog 1 (Drosophila) | retinol dehydrogenase 12 (all-trans/9-cis/11-cis); Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments | 0.819 |
| CRB1 | RPE65 | ENSP00000356370 | ENSP00000262340 | crumbs homolog 1 (Drosophila) | retinal pigment epithelium-specific protein 65kDa; Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis- retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of th [...] | 0.810 |
| CRB1 | TULP1 | ENSP00000356370 | ENSP00000229771 | crumbs homolog 1 (Drosophila) | tubby like protein 1; Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro) [...] | 0.804 |
| DNM1 | TULP1 | ENSP00000362014 | ENSP00000229771 | dynamin 1; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis | tubby like protein 1; Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro) [...] | 0.844 |
| PDE6A | AIPL1 | ENSP00000255266 | ENSP00000370521 | phosphodiesterase 6A, cGMP-specific, rod, alpha; This protein participates in processes of transmission and amplification of the visual signal | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | 0.511 |
| PDE6A | CRB1 | ENSP00000255266 | ENSP00000356370 | phosphodiesterase 6A, cGMP-specific, rod, alpha; This protein participates in processes of transmission and amplification of the visual signal | crumbs homolog 1 (Drosophila) | 0.507 |
| PDE6A | PDE6B | ENSP00000255266 | ENSP00000420295 | phosphodiesterase 6A, cGMP-specific, rod, alpha; This protein participates in processes of transmission and amplification of the visual signal | phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme | 0.901 |
| PDE6A | RDH12 | ENSP00000255266 | ENSP00000267502 | phosphodiesterase 6A, cGMP-specific, rod, alpha; This protein participates in processes of transmission and amplification of the visual signal | retinol dehydrogenase 12 (all-trans/9-cis/11-cis); Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments | 0.530 |
| PDE6A | RPE65 | ENSP00000255266 | ENSP00000262340 | phosphodiesterase 6A, cGMP-specific, rod, alpha; This protein participates in processes of transmission and amplification of the visual signal | retinal pigment epithelium-specific protein 65kDa; Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis- retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of th [...] | 0.804 |
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