node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GPR137C | GPR63 | ENSP00000315106 | ENSP00000229955 | G protein-coupled receptor 137C | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | 0.518 |
GPR137C | TM7SF3 | ENSP00000315106 | ENSP00000342322 | G protein-coupled receptor 137C | transmembrane 7 superfamily member 3 | 0.458 |
GPR3 | GPR63 | ENSP00000363136 | ENSP00000229955 | G protein-coupled receptor 3; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity) | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | 0.738 |
GPR6 | GPR63 | ENSP00000275169 | ENSP00000229955 | G protein-coupled receptor 6; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity) | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | 0.753 |
GPR6 | OXER1 | ENSP00000275169 | ENSP00000367930 | G protein-coupled receptor 6; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity) | oxoeicosanoid (OXE) receptor 1; Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins | 0.471 |
GPR62 | GPR63 | ENSP00000319250 | ENSP00000229955 | G protein-coupled receptor 62; Orphan receptor | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | 0.612 |
GPR63 | GPR137C | ENSP00000229955 | ENSP00000315106 | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | G protein-coupled receptor 137C | 0.518 |
GPR63 | GPR3 | ENSP00000229955 | ENSP00000363136 | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | G protein-coupled receptor 3; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity) | 0.738 |
GPR63 | GPR6 | ENSP00000229955 | ENSP00000275169 | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | G protein-coupled receptor 6; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity) | 0.753 |
GPR63 | GPR62 | ENSP00000229955 | ENSP00000319250 | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | G protein-coupled receptor 62; Orphan receptor | 0.612 |
GPR63 | KLHL32 | ENSP00000229955 | ENSP00000358265 | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | kelch-like 32 (Drosophila) | 0.607 |
GPR63 | OXER1 | ENSP00000229955 | ENSP00000367930 | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | oxoeicosanoid (OXE) receptor 1; Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins | 0.520 |
GPR63 | RAD1 | ENSP00000229955 | ENSP00000340879 | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | RAD1 homolog (S. pombe); Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3’-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity [...] | 0.493 |
GPR63 | STK17A | ENSP00000229955 | ENSP00000319192 | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | serine/threonine kinase 17a; Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species | 0.485 |
GPR63 | STK17B | ENSP00000229955 | ENSP00000263955 | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis | 0.524 |
GPR63 | TM7SF3 | ENSP00000229955 | ENSP00000342322 | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | transmembrane 7 superfamily member 3 | 0.484 |
KLHL32 | GPR63 | ENSP00000358265 | ENSP00000229955 | kelch-like 32 (Drosophila) | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | 0.607 |
OXER1 | GPR6 | ENSP00000367930 | ENSP00000275169 | oxoeicosanoid (OXE) receptor 1; Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins | G protein-coupled receptor 6; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity) | 0.471 |
OXER1 | GPR63 | ENSP00000367930 | ENSP00000229955 | oxoeicosanoid (OXE) receptor 1; Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | 0.520 |
RAD1 | GPR63 | ENSP00000340879 | ENSP00000229955 | RAD1 homolog (S. pombe); Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3’-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity [...] | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | 0.493 |