| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARF1 | CLTA | ENSP00000272102 | ENSP00000242285 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | 0.904 |
| ARF1 | CLTB | ENSP00000272102 | ENSP00000309415 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | 0.913 |
| ARF1 | COPA | ENSP00000272102 | ENSP00000357048 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | coatomer protein complex, subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the [...] | 0.964 |
| ARF1 | GPLD1 | ENSP00000272102 | ENSP00000230036 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | glycosylphosphatidylinositol specific phospholipase D1 | 0.917 |
| ARF1 | KDELR1 | ENSP00000272102 | ENSP00000329471 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L | 0.986 |
| ARF1 | KDELR2 | ENSP00000272102 | ENSP00000258739 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L | 0.950 |
| ARF1 | KDELR3 | ENSP00000272102 | ENSP00000386918 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity) | 0.949 |
| CLTA | ARF1 | ENSP00000242285 | ENSP00000272102 | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | 0.904 |
| CLTA | CLTB | ENSP00000242285 | ENSP00000309415 | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | 0.903 |
| CLTA | COPA | ENSP00000242285 | ENSP00000357048 | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | coatomer protein complex, subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the [...] | 0.902 |
| CLTA | GPLD1 | ENSP00000242285 | ENSP00000230036 | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | glycosylphosphatidylinositol specific phospholipase D1 | 0.900 |
| CLTA | KDELR1 | ENSP00000242285 | ENSP00000329471 | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L | 0.900 |
| CLTA | KDELR2 | ENSP00000242285 | ENSP00000258739 | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L | 0.900 |
| CLTA | KDELR3 | ENSP00000242285 | ENSP00000386918 | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity) | 0.900 |
| CLTB | ARF1 | ENSP00000309415 | ENSP00000272102 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] | 0.913 |
| CLTB | CLTA | ENSP00000309415 | ENSP00000242285 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | 0.903 |
| CLTB | COPA | ENSP00000309415 | ENSP00000357048 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | coatomer protein complex, subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the [...] | 0.906 |
| CLTB | GPLD1 | ENSP00000309415 | ENSP00000230036 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | glycosylphosphatidylinositol specific phospholipase D1 | 0.900 |
| CLTB | KDELR1 | ENSP00000309415 | ENSP00000329471 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L | 0.904 |
| CLTB | KDELR2 | ENSP00000309415 | ENSP00000258739 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L | 0.900 |
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