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SLC25A10 SLC25A10 MYOD1 MYOD1 MYOG MYOG HTR1B HTR1B TRPC1 TRPC1 MDFI MDFI NEU4 NEU4 KIF1A KIF1A CBFA2T2 CBFA2T2 CHIC2 CHIC2 PGLS PGLS
"MDFI" - MyoD family inhibitor in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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MDFIMyoD family inhibitor; Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the le [...] (246 aa)    
Predicted Functional Partners:
MYOD1
myogenic differentiation 1; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity) (320 aa)
        score_image   score_image   0.827
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (604 aa)
        score_image   score_image   0.787
HTR1B
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity (390 aa)
        score_image       0.753
MYOG
myogenin (myogenic factor 4); Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (224 aa)
        score_image   score_image   0.674
PGLS
6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate (258 aa)
        score_image       0.652
CHIC2
cysteine-rich hydrophobic domain 2 (165 aa)
        score_image   score_image   0.639
KIF1A
kinesin family member 1A (1690 aa)
        score_image       0.639
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10; Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane (287 aa)
        score_image       0.624
NEU4
sialidase 4; May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2’-(4-methylumbelliferyl)-alpha-D-N- acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids (497 aa)
        score_image       0.624
TRPC1
transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion (759 aa)
        score_image   score_image   0.613
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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