node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GTF2B | TAF1 | ENSP00000359531 | ENSP00000276072 | general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.996 |
GTF2B | TAF10 | ENSP00000359531 | ENSP00000299424 | general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors | 0.990 |
GTF2B | TAF11 | ENSP00000359531 | ENSP00000354633 | general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa; Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively) | 0.997 |
GTF2B | TAF12 | ENSP00000359531 | ENSP00000263974 | general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II | TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription | 0.979 |
GTF2B | TAF2 | ENSP00000359531 | ENSP00000367406 | general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II | TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter | 0.795 |
GTF2B | TAF4 | ENSP00000359531 | ENSP00000252996 | general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II | TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa; Makes part of TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone | 0.981 |
GTF2B | TAF5 | ENSP00000359531 | ENSP00000358854 | general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II | TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, a [...] | 0.973 |
GTF2B | TAF6 | ENSP00000359531 | ENSP00000399982 | general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II | TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors | 0.996 |
GTF2B | TAF7 | ENSP00000359531 | ENSP00000312709 | general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa; Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively) | 0.770 |
GTF2B | TBP | ENSP00000359531 | ENSP00000230354 | general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II | TATA box binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 wi [...] | 0.999 |
TAF1 | GTF2B | ENSP00000276072 | ENSP00000359531 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II | 0.996 |
TAF1 | TAF10 | ENSP00000276072 | ENSP00000299424 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors | 0.999 |
TAF1 | TAF11 | ENSP00000276072 | ENSP00000354633 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa; Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively) | 0.999 |
TAF1 | TAF12 | ENSP00000276072 | ENSP00000263974 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription | 0.999 |
TAF1 | TAF2 | ENSP00000276072 | ENSP00000367406 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter | 0.999 |
TAF1 | TAF4 | ENSP00000276072 | ENSP00000252996 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa; Makes part of TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone | 0.999 |
TAF1 | TAF5 | ENSP00000276072 | ENSP00000358854 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, a [...] | 0.999 |
TAF1 | TAF6 | ENSP00000276072 | ENSP00000399982 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors | 0.999 |
TAF1 | TAF7 | ENSP00000276072 | ENSP00000312709 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa; Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively) | 0.999 |
TAF1 | TBP | ENSP00000276072 | ENSP00000230354 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | TATA box binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 wi [...] | 0.999 |