| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BEST1 | PRPH2 | ENSP00000399709 | ENSP00000230381 | bestrophin 1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | 0.740 |
| CNGB1 | PDE6B | ENSP00000251102 | ENSP00000420295 | cyclic nucleotide gated channel beta 1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme | 0.947 |
| CNGB1 | PRPH2 | ENSP00000251102 | ENSP00000230381 | cyclic nucleotide gated channel beta 1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | 0.739 |
| CNGB1 | RHO | ENSP00000251102 | ENSP00000296271 | cyclic nucleotide gated channel beta 1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal | 0.499 |
| CTBP1 | PRPH2 | ENSP00000290921 | ENSP00000230381 | C-terminal binding protein 1; Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | 0.835 |
| MREG | PRPH2 | ENSP00000263268 | ENSP00000230381 | melanoregulin; Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity) | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | 0.815 |
| PDE6B | CNGB1 | ENSP00000420295 | ENSP00000251102 | phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme | cyclic nucleotide gated channel beta 1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | 0.947 |
| PDE6B | PRPH2 | ENSP00000420295 | ENSP00000230381 | phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | 0.875 |
| PDE6B | RD3 | ENSP00000420295 | ENSP00000355969 | phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme | retinal degeneration 3 | 0.757 |
| PDE6B | RHO | ENSP00000420295 | ENSP00000296271 | phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme | rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal | 0.725 |
| PRPF31 | PRPH2 | ENSP00000324122 | ENSP00000230381 | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | 0.672 |
| PRPF31 | RHO | ENSP00000324122 | ENSP00000296271 | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) | rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal | 0.543 |
| PRPF31 | RP9 | ENSP00000324122 | ENSP00000297157 | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) | retinitis pigmentosa 9 (autosomal dominant); Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1 (By similarity) | 0.803 |
| PRPH2 | BEST1 | ENSP00000230381 | ENSP00000399709 | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | bestrophin 1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate | 0.740 |
| PRPH2 | CNGB1 | ENSP00000230381 | ENSP00000251102 | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | cyclic nucleotide gated channel beta 1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | 0.739 |
| PRPH2 | CTBP1 | ENSP00000230381 | ENSP00000290921 | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | C-terminal binding protein 1; Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity | 0.835 |
| PRPH2 | MREG | ENSP00000230381 | ENSP00000263268 | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | melanoregulin; Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity) | 0.815 |
| PRPH2 | PDE6B | ENSP00000230381 | ENSP00000420295 | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme | 0.875 |
| PRPH2 | PRPF31 | ENSP00000230381 | ENSP00000324122 | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) | 0.672 |
| PRPH2 | RD3 | ENSP00000230381 | ENSP00000355969 | peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis | retinal degeneration 3 | 0.817 |
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