| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C6orf108 | DSTN | ENSP00000230431 | ENSP00000246069 | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | 0.718 |
| C6orf108 | MYC | ENSP00000230431 | ENSP00000367207 | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.842 |
| C6orf108 | NME1-NME2 | ENSP00000230431 | ENSP00000376886 | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | NME1-NME2 readthrough; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) | 0.418 |
| C6orf108 | NME2 | ENSP00000230431 | ENSP00000376889 | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | NME/NM23 nucleoside diphosphate kinase 2; Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed-8392752). Exhibits histidine protein kinase activity | 0.407 |
| C6orf108 | PRDX1 | ENSP00000230431 | ENSP00000262746 | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | peroxiredoxin 1; Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity) | 0.644 |
| C6orf108 | SSU72 | ENSP00000230431 | ENSP00000291386 | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae); Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK | 0.644 |
| C6orf108 | UBA1 | ENSP00000230431 | ENSP00000338413 | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | ubiquitin-like modifier activating enzyme 1; Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP | 0.644 |
| C6orf108 | UBC | ENSP00000230431 | ENSP00000344818 | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | ubiquitin C | 0.483 |
| C6orf108 | UBR1 | ENSP00000230431 | ENSP00000290650 | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | ubiquitin protein ligase E3 component n-recognin 1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth | 0.920 |
| C6orf108 | ZNF593 | ENSP00000230431 | ENSP00000363384 | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | zinc finger protein 593; Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins | 0.904 |
| DSTN | C6orf108 | ENSP00000246069 | ENSP00000230431 | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | 0.718 |
| DSTN | UBC | ENSP00000246069 | ENSP00000344818 | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | ubiquitin C | 0.969 |
| MYC | C6orf108 | ENSP00000367207 | ENSP00000230431 | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | 0.842 |
| MYC | NME1-NME2 | ENSP00000367207 | ENSP00000376886 | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | NME1-NME2 readthrough; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) | 0.899 |
| MYC | NME2 | ENSP00000367207 | ENSP00000376889 | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | NME/NM23 nucleoside diphosphate kinase 2; Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed-8392752). Exhibits histidine protein kinase activity | 0.991 |
| MYC | PRDX1 | ENSP00000367207 | ENSP00000262746 | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | peroxiredoxin 1; Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity) | 0.945 |
| MYC | UBC | ENSP00000367207 | ENSP00000344818 | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | ubiquitin C | 0.999 |
| NME1-NME2 | C6orf108 | ENSP00000376886 | ENSP00000230431 | NME1-NME2 readthrough; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | 0.418 |
| NME1-NME2 | MYC | ENSP00000376886 | ENSP00000367207 | NME1-NME2 readthrough; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | 0.899 |
| NME1-NME2 | NME2 | ENSP00000376886 | ENSP00000376889 | NME1-NME2 readthrough; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) | NME/NM23 nucleoside diphosphate kinase 2; Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed-8392752). Exhibits histidine protein kinase activity | 0.696 |
Share
