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ARID3A ARID3A LCORL LCORL ATOH7 ATOH7 ARID3C ARID3C ARID3B ARID3B POU4F3 POU4F3 LCOR LCOR ARID2 ARID2 GFI1 GFI1 BARHL1 BARHL1 ATOH1 ATOH1
"POU4F3" - POU class 4 homeobox 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
POU4F3POU class 4 homeobox 3; May play a role in determining or maintaining the identities of a small subset of visual system neurons (338 aa)    
Predicted Functional Partners:
GFI1
growth factor independent 1 transcription repressor; Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5’-TAAATCAC[AT]GCA-3’ in the promoter region of a large number of genes. Component of several complexes, including the EHMT2- GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required fo [...] (422 aa)
            score_image   0.751
ARID3C
AT rich interactive domain 3C (BRIGHT-like) (412 aa)
            score_image   0.733
ARID3B
AT rich interactive domain 3B (BRIGHT-like); Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A (560 aa)
            score_image   0.733
ARID3A
AT rich interactive domain 3A (BRIGHT-like); Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation (593 aa)
            score_image   0.733
BARHL1
BarH-like homeobox 1 (327 aa)
            score_image   0.724
LCOR
ligand dependent nuclear receptor corepressor; May act as transcription activator that binds DNA elements with the sequence 5’-CCCTATCGATCGATCTCTACCT-3’ (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand- dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR (433 aa)
            score_image   0.702
LCORL
ligand dependent nuclear receptor corepressor-like; May act as transcription activator that binds DNA elements with the sequence 5’-CCCTATCGATCGATCTCTACCT-3’. May play a role in spermatogenesis (By similarity) (602 aa)
            score_image   0.642
ATOH7
atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) (152 aa)
            score_image   0.641
ATOH1
atonal homolog 1 (Drosophila); Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity) (354 aa)
            score_image   0.626
ARID2
AT rich interactive domain 2 (ARID, RFX-like) (1835 aa)
            score_image   0.612
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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