NUDT12 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NUDT12

nudix (nucleoside diphosphate linked moiety X)-type motif 12; Hydrolyzes NAD(P)H to NMNH and AMP (2’,5’-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (462 aa)

Predicted Functional Partners:

ENSG00000250741

0.900

NAMPTL

0.900

NAPRT1

0.900

QPRT

0.900

NT5M

0.900

NMRK1

0.900

NADK

0.900

NT5C2

0.900

NADSYN1

0.900

BST1

0.900

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BST1	NADK	ENSP00000265016	ENSP00000340925	bone marrow stromal cell antigen 1; Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth	NAD kinase	0.914
BST1	NADSYN1	ENSP00000265016	ENSP00000326424	bone marrow stromal cell antigen 1; Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth	NAD synthetase 1	0.900
BST1	NAMPTL	ENSP00000265016	ENSP00000407952	bone marrow stromal cell antigen 1; Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth	nicotinamide phosphoribosyltransferase-like	0.900
BST1	NUDT12	ENSP00000265016	ENSP00000230792	bone marrow stromal cell antigen 1; Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth	nudix (nucleoside diphosphate linked moiety X)-type motif 12; Hydrolyzes NAD(P)H to NMNH and AMP (2’,5’-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle	0.900
BST1	QPRT	ENSP00000265016	ENSP00000378782	bone marrow stromal cell antigen 1; Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth	quinolinate phosphoribosyltransferase; Involved in the catabolism of quinolinic acid (QA)	0.566
ENSG00000250741	NAMPTL	ENSP00000433415	ENSP00000407952	NT5C1B-RDH14 readthrough	nicotinamide phosphoribosyltransferase-like	0.900
ENSG00000250741	NAPRT1	ENSP00000433415	ENSP00000401508	NT5C1B-RDH14 readthrough	nicotinate phosphoribosyltransferase domain containing 1; Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells	0.900
ENSG00000250741	NT5C2	ENSP00000433415	ENSP00000339479	NT5C1B-RDH14 readthrough	5’-nucleotidase, cytosolic II; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5’-monophosphate (IMP) and other purine nucleotides	0.560
ENSG00000250741	NUDT12	ENSP00000433415	ENSP00000230792	NT5C1B-RDH14 readthrough	nudix (nucleoside diphosphate linked moiety X)-type motif 12; Hydrolyzes NAD(P)H to NMNH and AMP (2’,5’-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle	0.900
ENSG00000250741	QPRT	ENSP00000433415	ENSP00000378782	NT5C1B-RDH14 readthrough	quinolinate phosphoribosyltransferase; Involved in the catabolism of quinolinic acid (QA)	0.900
NADK	BST1	ENSP00000340925	ENSP00000265016	NAD kinase	bone marrow stromal cell antigen 1; Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth	0.914
NADK	NADSYN1	ENSP00000340925	ENSP00000326424	NAD kinase	NAD synthetase 1	0.900
NADK	NUDT12	ENSP00000340925	ENSP00000230792	NAD kinase	nudix (nucleoside diphosphate linked moiety X)-type motif 12; Hydrolyzes NAD(P)H to NMNH and AMP (2’,5’-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle	0.900
NADK	QPRT	ENSP00000340925	ENSP00000378782	NAD kinase	quinolinate phosphoribosyltransferase; Involved in the catabolism of quinolinic acid (QA)	0.407
NADSYN1	BST1	ENSP00000326424	ENSP00000265016	NAD synthetase 1	bone marrow stromal cell antigen 1; Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth	0.900
NADSYN1	NADK	ENSP00000326424	ENSP00000340925	NAD synthetase 1	NAD kinase	0.900
NADSYN1	NAMPTL	ENSP00000326424	ENSP00000407952	NAD synthetase 1	nicotinamide phosphoribosyltransferase-like	0.838
NADSYN1	NAPRT1	ENSP00000326424	ENSP00000401508	NAD synthetase 1	nicotinate phosphoribosyltransferase domain containing 1; Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells	0.863
NADSYN1	NUDT12	ENSP00000326424	ENSP00000230792	NAD synthetase 1	nudix (nucleoside diphosphate linked moiety X)-type motif 12; Hydrolyzes NAD(P)H to NMNH and AMP (2’,5’-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle	0.900
NADSYN1	QPRT	ENSP00000326424	ENSP00000378782	NAD synthetase 1	quinolinate phosphoribosyltransferase; Involved in the catabolism of quinolinic acid (QA)	0.708

page 1 of 4

Experiments

Neighborhood

Databases

Cooccurrence

Textmining

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About