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PIPOX PIPOX GLDC GLDC GCAT GCAT SARDH SARDH GATM GATM AGXT2 AGXT2 ALAS2 ALAS2 AGXT AGXT GNMT GNMT SHMT2 SHMT2 SHMT1 SHMT1
"AGXT2" - alanine--glyoxylate aminotransferase 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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fusion edge
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coexpression edge
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protein homology
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Score
AGXT2alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (514 aa)    
Predicted Functional Partners:
AGXT
alanine-glyoxylate aminotransferase (392 aa)
      score_image   score_image score_image   0.988
GLDC
glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (1020 aa)
      score_image   score_image score_image   0.953
GATM
glycine amidinotransferase (L-arginine-glycine amidinotransferase); Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis (423 aa)
          score_image score_image   0.918
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA (504 aa)
          score_image score_image   0.913
SARDH
sarcosine dehydrogenase (918 aa)
      score_image   score_image score_image   0.909
GNMT
glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (295 aa)
      score_image   score_image score_image   0.909
ALAS2
aminolevulinate, delta-, synthase 2 (587 aa)
          score_image score_image   0.905
PIPOX
pipecolic acid oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline (390 aa)
      score_image   score_image     0.904
SHMT1
serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity) (483 aa)
          score_image score_image   0.900
GCAT
glycine C-acetyltransferase (445 aa)
          score_image     0.900
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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