node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSF2 | CSF2RB | ENSP00000296871 | ENSP00000384053 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | 0.999 |
CSF2 | IL2 | ENSP00000296871 | ENSP00000226730 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.992 |
CSF2 | IL3 | ENSP00000296871 | ENSP00000296870 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | interleukin 3 (colony-stimulating factor, multiple); Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages | 0.996 |
CSF2 | IL4 | ENSP00000296871 | ENSP00000231449 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes | 0.994 |
CSF2 | IL5 | ENSP00000296871 | ENSP00000231454 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | interleukin 5 (colony-stimulating factor, eosinophil); Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells | 0.962 |
CSF2 | IL5RA | ENSP00000296871 | ENSP00000256452 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | interleukin 5 receptor, alpha; This is the receptor for interleukin-5. The alpha chain binds to IL5 | 0.976 |
CSF2 | IL9 | ENSP00000296871 | ENSP00000274520 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | interleukin 9; Supports IL-2 independent and IL-4 independent growth of helper T-cells | 0.896 |
CSF2 | JUN | ENSP00000296871 | ENSP00000360266 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | 0.956 |
CSF2 | STAT6 | ENSP00000296871 | ENSP00000300134 | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | signal transducer and activator of transcription 6, interleukin-4 induced; Carries out a dual function- signal transduction and activation of transcription. Involved in interleukin-4 signalling | 0.507 |
CSF2RB | CSF2 | ENSP00000384053 | ENSP00000296871 | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes | 0.999 |
CSF2RB | IL2 | ENSP00000384053 | ENSP00000226730 | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.803 |
CSF2RB | IL3 | ENSP00000384053 | ENSP00000296870 | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | interleukin 3 (colony-stimulating factor, multiple); Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages | 0.998 |
CSF2RB | IL4 | ENSP00000384053 | ENSP00000231449 | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes | 0.806 |
CSF2RB | IL5 | ENSP00000384053 | ENSP00000231454 | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | interleukin 5 (colony-stimulating factor, eosinophil); Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells | 0.990 |
CSF2RB | IL5RA | ENSP00000384053 | ENSP00000256452 | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | interleukin 5 receptor, alpha; This is the receptor for interleukin-5. The alpha chain binds to IL5 | 0.992 |
CSF2RB | IL9 | ENSP00000384053 | ENSP00000274520 | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor | interleukin 9; Supports IL-2 independent and IL-4 independent growth of helper T-cells | 0.808 |
GATA3 | IL2 | ENSP00000368632 | ENSP00000226730 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.509 |
GATA3 | IL4 | ENSP00000368632 | ENSP00000231449 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes | 0.993 |
GATA3 | IL5 | ENSP00000368632 | ENSP00000231454 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | interleukin 5 (colony-stimulating factor, eosinophil); Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells | 0.991 |
GATA3 | IL9 | ENSP00000368632 | ENSP00000274520 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | interleukin 9; Supports IL-2 independent and IL-4 independent growth of helper T-cells | 0.416 |