node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDR1 | ZMYND10 | ENSP00000359563 | ENSP00000231749 | cerebellar degeneration-related protein 1, 34kDa | zinc finger, MYND-type containing 10 | 0.608 |
CTCF | ZMYND10 | ENSP00000264010 | ENSP00000231749 | CCCTC-binding factor (zinc finger protein); Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo devel [...] | zinc finger, MYND-type containing 10 | 0.803 |
CYB561D2 | NPRL2 | ENSP00000232508 | ENSP00000232501 | cytochrome b-561 domain containing 2 | nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs | 0.804 |
CYB561D2 | TUSC2 | ENSP00000232508 | ENSP00000232496 | cytochrome b-561 domain containing 2 | tumor suppressor candidate 2; May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells | 0.719 |
CYB561D2 | ZMYND10 | ENSP00000232508 | ENSP00000231749 | cytochrome b-561 domain containing 2 | zinc finger, MYND-type containing 10 | 0.793 |
IFT43 | ZMYND10 | ENSP00000238628 | ENSP00000231749 | intraflagellar transport 43 homolog (Chlamydomonas); Component of IFT complex A (IFT-A) involved in retrograde ciliary transport along microtubules from the ciliary tip to the base | zinc finger, MYND-type containing 10 | 0.581 |
LRRC6 | ZMYND10 | ENSP00000250173 | ENSP00000231749 | leucine rich repeat containing 6; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility | zinc finger, MYND-type containing 10 | 0.869 |
NPRL2 | CYB561D2 | ENSP00000232501 | ENSP00000232508 | nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs | cytochrome b-561 domain containing 2 | 0.804 |
NPRL2 | TUSC2 | ENSP00000232501 | ENSP00000232496 | nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs | tumor suppressor candidate 2; May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells | 0.715 |
NPRL2 | ZMYND10 | ENSP00000232501 | ENSP00000231749 | nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs | zinc finger, MYND-type containing 10 | 0.728 |
PRSS3 | ZMYND10 | ENSP00000354280 | ENSP00000231749 | protease, serine, 3; Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5 | zinc finger, MYND-type containing 10 | 0.811 |
RUNX1T1 | ZMYND10 | ENSP00000402257 | ENSP00000231749 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | zinc finger, MYND-type containing 10 | 0.683 |
SASS6 | ZMYND10 | ENSP00000287482 | ENSP00000231749 | spindle assembly 6 homolog (C. elegans); Required for centrosome duplication. Overexpression results in excess foci-bearing centriolar markers | zinc finger, MYND-type containing 10 | 0.587 |
TUSC2 | CYB561D2 | ENSP00000232496 | ENSP00000232508 | tumor suppressor candidate 2; May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells | cytochrome b-561 domain containing 2 | 0.719 |
TUSC2 | NPRL2 | ENSP00000232496 | ENSP00000232501 | tumor suppressor candidate 2; May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells | nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs | 0.715 |
TUSC2 | ZMYND10 | ENSP00000232496 | ENSP00000231749 | tumor suppressor candidate 2; May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells | zinc finger, MYND-type containing 10 | 0.726 |
ZMYND10 | CDR1 | ENSP00000231749 | ENSP00000359563 | zinc finger, MYND-type containing 10 | cerebellar degeneration-related protein 1, 34kDa | 0.608 |
ZMYND10 | CTCF | ENSP00000231749 | ENSP00000264010 | zinc finger, MYND-type containing 10 | CCCTC-binding factor (zinc finger protein); Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo devel [...] | 0.803 |
ZMYND10 | CYB561D2 | ENSP00000231749 | ENSP00000232508 | zinc finger, MYND-type containing 10 | cytochrome b-561 domain containing 2 | 0.793 |
ZMYND10 | IFT43 | ENSP00000231749 | ENSP00000238628 | zinc finger, MYND-type containing 10 | intraflagellar transport 43 homolog (Chlamydomonas); Component of IFT complex A (IFT-A) involved in retrograde ciliary transport along microtubules from the ciliary tip to the base | 0.581 |