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IFRD2 IFRD2 SUFU SUFU KIF7 KIF7 KIF27 KIF27 SGOL2 SGOL2 TUSC2 TUSC2 CASP3 CASP3 HIC2 HIC2 NPRL2 NPRL2 CYB561D2 CYB561D2 ZMYND10 ZMYND10
"TUSC2" - tumor suppressor candidate 2 in Homo sapiens
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TUSC2tumor suppressor candidate 2; May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells (110 aa)    
Predicted Functional Partners:
SUFU
suppressor of fused homolog (Drosophila); Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full len [...] (484 aa)
            score_image   0.758
ZMYND10
zinc finger, MYND-type containing 10 (440 aa)
            score_image   0.726
CYB561D2
cytochrome b-561 domain containing 2 (222 aa)
            score_image   0.719
NPRL2
nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs (380 aa)
            score_image   0.715
KIF7
kinesin family member 7; Acts as both a negative and positive regulator of sonic hedgehog (Shh) pathway, acting downstream of SMO. Negatively regulates the pathway by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates the pathway by preventing the processing of the transcription factor GLI3 into its repressor form. Required for efficient localization of GLI3 to cilia in response to Shh. Affects microtubular dynamics and acts as a ciliary motor (1343 aa)
            score_image   0.563
KIF27
kinesin family member 27; Plays an essential role in motile ciliogenesis (By similarity) (1401 aa)
            score_image   0.561
HIC2
hypermethylated in cancer 2; Transcriptional repressor (615 aa)
            score_image   0.523
CASP3
caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (277 aa)
            score_image   0.512
IFRD2
interferon-related developmental regulator 2 (506 aa)
            score_image   0.464
SGOL2
shugoshin-like 2 (S. pombe); Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Ess [...] (1265 aa)
        score_image       0.454
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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