NPRL2 protein (Homo sapiens) - STRING network view

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NPRL2

nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs (380 aa)

Predicted Functional Partners:

NPRL3

0.972

PDPK1

0.817

DEPDC5

0.814

CYB561D2

0.804

GRN

0.758

ZMYND10

0.728

TUSC2

0.715

UBC

0.709

PRKAR1A

0.649

CACNA2D2

0.643

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACNA2D2	CYB561D2	ENSP00000418081	ENSP00000232508	calcium channel, voltage-dependent, alpha 2/delta subunit 2; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis	cytochrome b-561 domain containing 2	0.550
CACNA2D2	NPRL2	ENSP00000418081	ENSP00000232501	calcium channel, voltage-dependent, alpha 2/delta subunit 2; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis	nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs	0.643
CACNA2D2	ZMYND10	ENSP00000418081	ENSP00000231749	calcium channel, voltage-dependent, alpha 2/delta subunit 2; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis	zinc finger, MYND-type containing 10	0.546
CYB561D2	CACNA2D2	ENSP00000232508	ENSP00000418081	cytochrome b-561 domain containing 2	calcium channel, voltage-dependent, alpha 2/delta subunit 2; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis	0.550
CYB561D2	NPRL2	ENSP00000232508	ENSP00000232501	cytochrome b-561 domain containing 2	nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs	0.804
CYB561D2	TUSC2	ENSP00000232508	ENSP00000232496	cytochrome b-561 domain containing 2	tumor suppressor candidate 2; May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells	0.719
CYB561D2	ZMYND10	ENSP00000232508	ENSP00000231749	cytochrome b-561 domain containing 2	zinc finger, MYND-type containing 10	0.793
DEPDC5	NPRL2	ENSP00000371546	ENSP00000232501	DEP domain containing 5	nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs	0.814
DEPDC5	NPRL3	ENSP00000371546	ENSP00000382834	DEP domain containing 5	nitrogen permease regulator-like 3 (S. cerevisiae)	0.776
DEPDC5	UBC	ENSP00000371546	ENSP00000344818	DEP domain containing 5	ubiquitin C	0.406
GRN	NPRL2	ENSP00000053867	ENSP00000232501	granulin	nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs	0.758
NPRL2	CACNA2D2	ENSP00000232501	ENSP00000418081	nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs	calcium channel, voltage-dependent, alpha 2/delta subunit 2; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis	0.643
NPRL2	CYB561D2	ENSP00000232501	ENSP00000232508	nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs	cytochrome b-561 domain containing 2	0.804
NPRL2	DEPDC5	ENSP00000232501	ENSP00000371546	nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs	DEP domain containing 5	0.814
NPRL2	GRN	ENSP00000232501	ENSP00000053867	nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs	granulin	0.758
NPRL2	NPRL3	ENSP00000232501	ENSP00000382834	nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs	nitrogen permease regulator-like 3 (S. cerevisiae)	0.972
NPRL2	PDPK1	ENSP00000232501	ENSP00000344220	nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs	3-phosphoinositide dependent protein kinase-1; Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include- protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central rol [...]	0.817
NPRL2	PRKAR1A	ENSP00000232501	ENSP00000351410	nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs	protein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells	0.649
NPRL2	TUSC2	ENSP00000232501	ENSP00000232496	nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs	tumor suppressor candidate 2; May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells	0.715
NPRL2	UBC	ENSP00000232501	ENSP00000344818	nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs	ubiquitin C	0.709

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