MORC1 protein (Homo sapiens) - STRING network view

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MORC1

MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity) (984 aa)

Predicted Functional Partners:

MEI1

0.756

SPO11

0.607

DMRTB1

0.513

SUN1

0.493

SUN2

0.477

CTCFL

0.475

GBAS

0.461

NIPSNAP1

0.461

DDX25

0.452

LIN7B

0.441

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTCFL	MORC1	ENSP00000243914	ENSP00000232603	CCCTC-binding factor (zinc finger protein)-like	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	0.475
DDX25	LIN7B	ENSP00000263576	ENSP00000221459	DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity)	lin-7 homolog B (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...]	0.448
DDX25	MORC1	ENSP00000263576	ENSP00000232603	DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity)	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	0.452
DMRTB1	MORC1	ENSP00000360500	ENSP00000232603	DMRT-like family B with proline-rich C-terminal, 1	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	0.513
GBAS	MORC1	ENSP00000313050	ENSP00000232603	glioblastoma amplified sequence	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	0.461
GBAS	NIPSNAP1	ENSP00000313050	ENSP00000216121	glioblastoma amplified sequence	nipsnap homolog 1 (C. elegans)	0.939
LIN7B	DDX25	ENSP00000221459	ENSP00000263576	lin-7 homolog B (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...]	DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity)	0.448
LIN7B	MORC1	ENSP00000221459	ENSP00000232603	lin-7 homolog B (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...]	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	0.441
MEI1	MORC1	ENSP00000384115	ENSP00000232603	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	0.756
MEI1	SPO11	ENSP00000384115	ENSP00000360310	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae); Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity)	0.680
MORC1	CTCFL	ENSP00000232603	ENSP00000243914	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	CCCTC-binding factor (zinc finger protein)-like	0.475
MORC1	DDX25	ENSP00000232603	ENSP00000263576	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity)	0.452
MORC1	DMRTB1	ENSP00000232603	ENSP00000360500	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	DMRT-like family B with proline-rich C-terminal, 1	0.513
MORC1	GBAS	ENSP00000232603	ENSP00000313050	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	glioblastoma amplified sequence	0.461
MORC1	LIN7B	ENSP00000232603	ENSP00000221459	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	lin-7 homolog B (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...]	0.441
MORC1	MEI1	ENSP00000232603	ENSP00000384115	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)	0.756
MORC1	NIPSNAP1	ENSP00000232603	ENSP00000216121	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	nipsnap homolog 1 (C. elegans)	0.461
MORC1	SPO11	ENSP00000232603	ENSP00000360310	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae); Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity)	0.607
MORC1	SUN1	ENSP00000232603	ENSP00000384015	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	Sad1 and UNC84 domain containing 1	0.493
MORC1	SUN2	ENSP00000232603	ENSP00000385616	MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity)	Sad1 and UNC84 domain containing 2; Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus co [...]	0.477

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