node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABTB1 | CUL3 | ENSP00000232744 | ENSP00000264414 | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | 0.873 |
ABTB1 | CUL4A | ENSP00000232744 | ENSP00000364589 | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | cullin 4A; Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on [...] | 0.672 |
ABTB1 | CUL4B | ENSP00000232744 | ENSP00000384109 | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | cullin 4B | 0.672 |
ABTB1 | DNTTIP1 | ENSP00000232744 | ENSP00000361705 | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | deoxynucleotidyltransferase, terminal, interacting protein 1; Shown to enhance TdT activity, in vitro | 0.651 |
ABTB1 | EEF1A2 | ENSP00000232744 | ENSP00000217182 | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | eukaryotic translation elongation factor 1 alpha 2; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis | 0.612 |
ABTB1 | GJB5 | ENSP00000232744 | ENSP00000340811 | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | gap junction protein, beta 5, 31.1kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell | 0.598 |
ABTB1 | LY6E | ENSP00000232744 | ENSP00000292494 | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | lymphocyte antigen 6 complex, locus E | 0.584 |
ABTB1 | RBX1 | ENSP00000232744 | ENSP00000216225 | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | ring-box 1, E3 ubiquitin protein ligase; E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in pr [...] | 0.743 |
ABTB1 | RNF7 | ENSP00000232744 | ENSP00000273480 | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | ring finger protein 7; Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents | 0.666 |
ABTB1 | SLC4A1 | ENSP00000232744 | ENSP00000262418 | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1-1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin | 0.748 |
CUL3 | ABTB1 | ENSP00000264414 | ENSP00000232744 | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | 0.873 |
CUL3 | RBX1 | ENSP00000264414 | ENSP00000216225 | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | ring-box 1, E3 ubiquitin protein ligase; E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in pr [...] | 0.999 |
CUL3 | RNF7 | ENSP00000264414 | ENSP00000273480 | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | ring finger protein 7; Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents | 0.892 |
CUL4A | ABTB1 | ENSP00000364589 | ENSP00000232744 | cullin 4A; Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on [...] | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | 0.672 |
CUL4A | CUL4B | ENSP00000364589 | ENSP00000384109 | cullin 4A; Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on [...] | cullin 4B | 0.992 |
CUL4A | RBX1 | ENSP00000364589 | ENSP00000216225 | cullin 4A; Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on [...] | ring-box 1, E3 ubiquitin protein ligase; E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in pr [...] | 0.999 |
CUL4A | RNF7 | ENSP00000364589 | ENSP00000273480 | cullin 4A; Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on [...] | ring finger protein 7; Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents | 0.972 |
CUL4B | ABTB1 | ENSP00000384109 | ENSP00000232744 | cullin 4B | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | 0.672 |
CUL4B | CUL4A | ENSP00000384109 | ENSP00000364589 | cullin 4B | cullin 4A; Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on [...] | 0.992 |
CUL4B | RBX1 | ENSP00000384109 | ENSP00000216225 | cullin 4B | ring-box 1, E3 ubiquitin protein ligase; E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in pr [...] | 0.999 |