TNNC1 protein (Homo sapiens) - STRING network view

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TNNC1

troponin C type 1 (slow); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments (161 aa)

Predicted Functional Partners:

TNNI3

0.999

TNNT2

0.999

TNNI1

0.997

TNNT1

0.993

TNNI2

0.988

MYH6

0.978

TPM1

0.972

MYH3

0.961

MYBPC3

0.959

MYH8

0.955

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MYBPC3	MYH3	ENSP00000442795	ENSP00000226209	myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction	0.901
MYBPC3	MYH6	ENSP00000442795	ENSP00000348634	myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction	0.980
MYBPC3	MYH8	ENSP00000442795	ENSP00000384330	myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction	0.900
MYBPC3	TNNC1	ENSP00000442795	ENSP00000232975	myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	troponin C type 1 (slow); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments	0.959
MYBPC3	TNNI1	ENSP00000442795	ENSP00000337022	myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	troponin I type 1 (skeletal, slow)	0.939
MYBPC3	TNNI2	ENSP00000442795	ENSP00000252898	myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	troponin I type 2 (skeletal, fast); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity	0.925
MYBPC3	TNNI3	ENSP00000442795	ENSP00000341838	myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	troponin I type 3 (cardiac); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity	0.975
MYBPC3	TNNT1	ENSP00000442795	ENSP00000467176	myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	troponin T type 1 (skeletal, slow); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity	0.949
MYBPC3	TNNT2	ENSP00000442795	ENSP00000356286	myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	troponin T type 2 (cardiac); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity	0.981
MYBPC3	TPM1	ENSP00000442795	ENSP00000267996	myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	tropomyosin 1 (alpha)	0.970
MYH3	MYBPC3	ENSP00000226209	ENSP00000442795	myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction	myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	0.901
MYH3	MYH6	ENSP00000226209	ENSP00000348634	myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction	myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction	0.900
MYH3	MYH8	ENSP00000226209	ENSP00000384330	myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction	myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction	0.900
MYH3	TNNC1	ENSP00000226209	ENSP00000232975	myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction	troponin C type 1 (slow); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments	0.961
MYH3	TNNI1	ENSP00000226209	ENSP00000337022	myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction	troponin I type 1 (skeletal, slow)	0.977
MYH3	TNNI2	ENSP00000226209	ENSP00000252898	myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction	troponin I type 2 (skeletal, fast); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity	0.994
MYH3	TNNI3	ENSP00000226209	ENSP00000341838	myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction	troponin I type 3 (cardiac); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity	0.971
MYH3	TNNT1	ENSP00000226209	ENSP00000467176	myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction	troponin T type 1 (skeletal, slow); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity	0.939
MYH3	TNNT2	ENSP00000226209	ENSP00000356286	myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction	troponin T type 2 (cardiac); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity	0.961
MYH3	TPM1	ENSP00000226209	ENSP00000267996	myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction	tropomyosin 1 (alpha)	0.967

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