node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MYBPC3 | MYH3 | ENSP00000442795 | ENSP00000226209 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | 0.901 |
MYBPC3 | MYH6 | ENSP00000442795 | ENSP00000348634 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | 0.980 |
MYBPC3 | MYH8 | ENSP00000442795 | ENSP00000384330 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction | 0.900 |
MYBPC3 | TNNC1 | ENSP00000442795 | ENSP00000232975 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | troponin C type 1 (slow); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments | 0.959 |
MYBPC3 | TNNI1 | ENSP00000442795 | ENSP00000337022 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | troponin I type 1 (skeletal, slow) | 0.939 |
MYBPC3 | TNNI2 | ENSP00000442795 | ENSP00000252898 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | troponin I type 2 (skeletal, fast); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.925 |
MYBPC3 | TNNI3 | ENSP00000442795 | ENSP00000341838 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | troponin I type 3 (cardiac); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.975 |
MYBPC3 | TNNT1 | ENSP00000442795 | ENSP00000467176 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | troponin T type 1 (skeletal, slow); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.949 |
MYBPC3 | TNNT2 | ENSP00000442795 | ENSP00000356286 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | troponin T type 2 (cardiac); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.981 |
MYBPC3 | TPM1 | ENSP00000442795 | ENSP00000267996 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | tropomyosin 1 (alpha) | 0.970 |
MYH3 | MYBPC3 | ENSP00000226209 | ENSP00000442795 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | 0.901 |
MYH3 | MYH6 | ENSP00000226209 | ENSP00000348634 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | 0.900 |
MYH3 | MYH8 | ENSP00000226209 | ENSP00000384330 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction | 0.900 |
MYH3 | TNNC1 | ENSP00000226209 | ENSP00000232975 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | troponin C type 1 (slow); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments | 0.961 |
MYH3 | TNNI1 | ENSP00000226209 | ENSP00000337022 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | troponin I type 1 (skeletal, slow) | 0.977 |
MYH3 | TNNI2 | ENSP00000226209 | ENSP00000252898 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | troponin I type 2 (skeletal, fast); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.994 |
MYH3 | TNNI3 | ENSP00000226209 | ENSP00000341838 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | troponin I type 3 (cardiac); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.971 |
MYH3 | TNNT1 | ENSP00000226209 | ENSP00000467176 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | troponin T type 1 (skeletal, slow); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.939 |
MYH3 | TNNT2 | ENSP00000226209 | ENSP00000356286 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | troponin T type 2 (cardiac); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.961 |
MYH3 | TPM1 | ENSP00000226209 | ENSP00000267996 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | tropomyosin 1 (alpha) | 0.967 |