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STRINGSTRING
PLEKHA4 PLEKHA4 PMEL PMEL PDE6B PDE6B TMSB10 TMSB10 TMOD1 TMOD1 ZNF740 ZNF740 GPNMB GPNMB UBC UBC VEGFA VEGFA BAMBI BAMBI YRDC YRDC
"TMSB10" - thymosin beta 10 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
TMSB10thymosin beta 10; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity) (44 aa)    
Predicted Functional Partners:
VEGFA
vascular endothelial growth factor A (412 aa)
             score_image   0.844
BAMBI
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) (260 aa)
             score_image   0.800
PMEL
premelanosome protein; Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity (668 aa)
             score_image   0.757
UBC
ubiquitin C (685 aa)
         score_image   score_image   0.729
GPNMB
glycoprotein (transmembrane) nmb; Could be a melanogenic enzyme (By similarity) (572 aa)
             score_image   0.687
YRDC
yrdC domain containing (E. coli); May regulate the activity of some transporters (By similarity) (279 aa)
         score_image       0.644
TMOD1
tropomodulin 1; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus (359 aa)
         score_image   score_image   0.602
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme (854 aa)
             score_image   0.561
PLEKHA4
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides (779 aa)
             score_image   0.558
ZNF740
zinc finger protein 740; May be involved in transcriptional regulation (193 aa)
             score_image   0.514
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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