| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARSA | GAL3ST1 | ENSP00000216124 | ENSP00000343234 | arylsulfatase A; Hydrolyzes cerebroside sulfate | galactose-3-O-sulfotransferase 1; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro) | 0.868 |
| ARSA | GALC | ENSP00000216124 | ENSP00000261304 | arylsulfatase A; Hydrolyzes cerebroside sulfate | galactosylceramidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon | 0.959 |
| ARSA | NEU2 | ENSP00000216124 | ENSP00000233840 | arylsulfatase A; Hydrolyzes cerebroside sulfate | sialidase 2 (cytosolic sialidase); Hydrolyzes sialylated compounds | 0.900 |
| ARSA | UGT8 | ENSP00000216124 | ENSP00000311648 | arylsulfatase A; Hydrolyzes cerebroside sulfate | UDP glycosyltransferase 8; Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system | 0.920 |
| CAV1 | GRB2 | ENSP00000339191 | ENSP00000339007 | caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.927 |
| CAV1 | NEU2 | ENSP00000339191 | ENSP00000233840 | caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway | sialidase 2 (cytosolic sialidase); Hydrolyzes sialylated compounds | 0.622 |
| DTYMK | GAL3ST2 | ENSP00000304802 | ENSP00000192314 | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | galactose-3-O-sulfotransferase 2; Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal- beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency | 0.860 |
| DTYMK | NEU2 | ENSP00000304802 | ENSP00000233840 | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | sialidase 2 (cytosolic sialidase); Hydrolyzes sialylated compounds | 0.740 |
| GAL3ST1 | ARSA | ENSP00000343234 | ENSP00000216124 | galactose-3-O-sulfotransferase 1; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro) | arylsulfatase A; Hydrolyzes cerebroside sulfate | 0.868 |
| GAL3ST1 | GALC | ENSP00000343234 | ENSP00000261304 | galactose-3-O-sulfotransferase 1; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro) | galactosylceramidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon | 0.948 |
| GAL3ST1 | NEU2 | ENSP00000343234 | ENSP00000233840 | galactose-3-O-sulfotransferase 1; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro) | sialidase 2 (cytosolic sialidase); Hydrolyzes sialylated compounds | 0.900 |
| GAL3ST1 | UGT8 | ENSP00000343234 | ENSP00000311648 | galactose-3-O-sulfotransferase 1; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro) | UDP glycosyltransferase 8; Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system | 0.948 |
| GAL3ST2 | DTYMK | ENSP00000192314 | ENSP00000304802 | galactose-3-O-sulfotransferase 2; Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal- beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | 0.860 |
| GAL3ST2 | NEU2 | ENSP00000192314 | ENSP00000233840 | galactose-3-O-sulfotransferase 2; Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal- beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency | sialidase 2 (cytosolic sialidase); Hydrolyzes sialylated compounds | 0.744 |
| GALC | ARSA | ENSP00000261304 | ENSP00000216124 | galactosylceramidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon | arylsulfatase A; Hydrolyzes cerebroside sulfate | 0.959 |
| GALC | GAL3ST1 | ENSP00000261304 | ENSP00000343234 | galactosylceramidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon | galactose-3-O-sulfotransferase 1; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro) | 0.948 |
| GALC | NEU2 | ENSP00000261304 | ENSP00000233840 | galactosylceramidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon | sialidase 2 (cytosolic sialidase); Hydrolyzes sialylated compounds | 0.901 |
| GALC | UGT8 | ENSP00000261304 | ENSP00000311648 | galactosylceramidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon | UDP glycosyltransferase 8; Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system | 0.878 |
| GRB2 | CAV1 | ENSP00000339007 | ENSP00000339191 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway | 0.927 |
| GRB2 | NEU2 | ENSP00000339007 | ENSP00000233840 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | sialidase 2 (cytosolic sialidase); Hydrolyzes sialylated compounds | 0.656 |
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