| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCR5 | IFNG | ENSP00000292303 | ENSP00000229135 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | 0.420 |
| CCR5 | IL18 | ENSP00000292303 | ENSP00000280357 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | interleukin 18 (interferon-gamma-inducing factor); Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells | 0.917 |
| CCR5 | IL18R1 | ENSP00000292303 | ENSP00000233957 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | interleukin 18 receptor 1; Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B | 0.906 |
| CCR5 | IL18RAP | ENSP00000292303 | ENSP00000264260 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | interleukin 18 receptor accessory protein; Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK | 0.906 |
| CCR5 | JUN | ENSP00000292303 | ENSP00000360266 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | 0.923 |
| IFNG | CCR5 | ENSP00000229135 | ENSP00000292303 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | chemokine (C-C motif) receptor 5 (gene/pseudogene) | 0.420 |
| IFNG | IL18 | ENSP00000229135 | ENSP00000280357 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | interleukin 18 (interferon-gamma-inducing factor); Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells | 0.957 |
| IFNG | IL18R1 | ENSP00000229135 | ENSP00000233957 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | interleukin 18 receptor 1; Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B | 0.982 |
| IFNG | IL18RAP | ENSP00000229135 | ENSP00000264260 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | interleukin 18 receptor accessory protein; Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK | 0.916 |
| IFNG | JUN | ENSP00000229135 | ENSP00000360266 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | 0.932 |
| IFNG | MAPK9 | ENSP00000229135 | ENSP00000389338 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | mitogen-activated protein kinase 9 | 0.920 |
| IFNG | NFKB1 | ENSP00000229135 | ENSP00000226574 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to b [...] | 0.688 |
| IFNG | STAT4 | ENSP00000229135 | ENSP00000351255 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | signal transducer and activator of transcription 4; Carries out a dual function- signal transduction and activation of transcription. Involved in IL12 signaling | 0.949 |
| IL13 | IL18 | ENSP00000304915 | ENSP00000280357 | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | interleukin 18 (interferon-gamma-inducing factor); Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells | 0.951 |
| IL13 | IL18R1 | ENSP00000304915 | ENSP00000233957 | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | interleukin 18 receptor 1; Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B | 0.912 |
| IL13 | IL18RAP | ENSP00000304915 | ENSP00000264260 | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | interleukin 18 receptor accessory protein; Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK | 0.911 |
| IL13 | JUN | ENSP00000304915 | ENSP00000360266 | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | 0.938 |
| IL13 | NFKB1 | ENSP00000304915 | ENSP00000226574 | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to b [...] | 0.512 |
| IL13 | STAT4 | ENSP00000304915 | ENSP00000351255 | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | signal transducer and activator of transcription 4; Carries out a dual function- signal transduction and activation of transcription. Involved in IL12 signaling | 0.917 |
| IL18 | CCR5 | ENSP00000280357 | ENSP00000292303 | interleukin 18 (interferon-gamma-inducing factor); Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells | chemokine (C-C motif) receptor 5 (gene/pseudogene) | 0.917 |
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