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STRINGSTRING
MYB MYB CEBPA CEBPA SERPINB1 SERPINB1 SPI1 SPI1 CEBPD CEBPD PRTN3 PRTN3 CEBPB CEBPB IL8 IL8 F2RL1 F2RL1 CD177 CD177 IL32 IL32
"PRTN3" - proteinase 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
PRTN3proteinase 3 (256 aa)    
Predicted Functional Partners:
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1; Binds to the PU-box, a purine-rich DNA sequence (5’- GAGGAA-3’) that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity) (271 aa)
          score_image score_image   0.986
IL32
interleukin 32 (188 aa)
        score_image   score_image   0.964
MYB
v-myb myeloblastosis viral oncogene homolog (avian) (761 aa)
          score_image score_image   0.931
SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1; Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H (379 aa)
score_image       score_image   score_image   0.924
CEBPA
CCAAT/enhancer binding protein (C/EBP), alpha; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (358 aa)
          score_image score_image   0.922
F2RL1
coagulation factor II (thrombin) receptor-like 1; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can sig [...] (397 aa)
        score_image   score_image   0.916
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta; Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5’-T[TG]NNGNAA[TG]-3’. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proli [...] (345 aa)
          score_image score_image   0.913
IL8
interleukin 8 (99 aa)
            score_image   0.909
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages (269 aa)
          score_image score_image   0.905
CD177
CD177 molecule (248 aa)
            score_image   0.896
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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