VAX2 protein (Homo sapiens) - STRING network view

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VAX2

ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina (290 aa)

Predicted Functional Partners:

TBX5

0.665

NKX6-3

0.628

PAX2

0.581

KAZN

0.552

LEUTX

0.510

SIX3

0.501

ARGFX

0.499

ALDH1A3

0.477

SIX6

0.460

ATOH7

0.432

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A3	VAX2	ENSP00000332256	ENSP00000234392	aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity)	ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina	0.477
ARGFX	PAX2	ENSP00000335578	ENSP00000396259	arginine-fifty homeobox; Putative transcription factor (By similarity)	paired box 2; Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS	0.451
ARGFX	SIX3	ENSP00000335578	ENSP00000260653	arginine-fifty homeobox; Putative transcription factor (By similarity)	SIX homeobox 3; May be involved in visual system development	0.607
ARGFX	SIX6	ENSP00000335578	ENSP00000328596	arginine-fifty homeobox; Putative transcription factor (By similarity)	SIX homeobox 6; May be involved in eye development	0.619
ARGFX	VAX2	ENSP00000335578	ENSP00000234392	arginine-fifty homeobox; Putative transcription factor (By similarity)	ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina	0.499
ATOH7	SIX3	ENSP00000362777	ENSP00000260653	atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity)	SIX homeobox 3; May be involved in visual system development	0.585
ATOH7	SIX6	ENSP00000362777	ENSP00000328596	atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity)	SIX homeobox 6; May be involved in eye development	0.539
ATOH7	VAX2	ENSP00000362777	ENSP00000234392	atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity)	ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina	0.432
KAZN	VAX2	ENSP00000365198	ENSP00000234392	kazrin, periplakin interacting protein	ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina	0.552
LEUTX	PAX2	ENSP00000380053	ENSP00000396259	leucine twenty homeobox	paired box 2; Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS	0.451
LEUTX	SIX3	ENSP00000380053	ENSP00000260653	leucine twenty homeobox	SIX homeobox 3; May be involved in visual system development	0.607
LEUTX	SIX6	ENSP00000380053	ENSP00000328596	leucine twenty homeobox	SIX homeobox 6; May be involved in eye development	0.628
LEUTX	VAX2	ENSP00000380053	ENSP00000234392	leucine twenty homeobox	ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina	0.510
NKX6-3	VAX2	ENSP00000429553	ENSP00000234392	NK6 homeobox 3; Putative transcription factor, which may be involved in patterning of central nervous system and pancreas (By similarity)	ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina	0.628
PAX2	ARGFX	ENSP00000396259	ENSP00000335578	paired box 2; Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS	arginine-fifty homeobox; Putative transcription factor (By similarity)	0.451
PAX2	LEUTX	ENSP00000396259	ENSP00000380053	paired box 2; Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS	leucine twenty homeobox	0.451
PAX2	SIX3	ENSP00000396259	ENSP00000260653	paired box 2; Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS	SIX homeobox 3; May be involved in visual system development	0.742
PAX2	SIX6	ENSP00000396259	ENSP00000328596	paired box 2; Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS	SIX homeobox 6; May be involved in eye development	0.633
PAX2	VAX2	ENSP00000396259	ENSP00000234392	paired box 2; Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS	ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina	0.581
SIX3	ARGFX	ENSP00000260653	ENSP00000335578	SIX homeobox 3; May be involved in visual system development	arginine-fifty homeobox; Putative transcription factor (By similarity)	0.607

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