node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCB1 | CLCN6 | ENSP00000265724 | ENSP00000234488 | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | chloride channel, voltage-sensitive 6 | 0.488 |
ABCB1 | MTHFR | ENSP00000265724 | ENSP00000365775 | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | 0.474 |
ABCB1 | UBC | ENSP00000265724 | ENSP00000344818 | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | ubiquitin C | 0.986 |
AMD1 | CLCN6 | ENSP00000357880 | ENSP00000234488 | adenosylmethionine decarboxylase 1 | chloride channel, voltage-sensitive 6 | 0.660 |
AMD1 | OSTM1 | ENSP00000357880 | ENSP00000193322 | adenosylmethionine decarboxylase 1 | osteopetrosis associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function (By similarity) | 0.758 |
AMD1 | UBC | ENSP00000357880 | ENSP00000344818 | adenosylmethionine decarboxylase 1 | ubiquitin C | 0.626 |
CLCN6 | ABCB1 | ENSP00000234488 | ENSP00000265724 | chloride channel, voltage-sensitive 6 | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | 0.488 |
CLCN6 | AMD1 | ENSP00000234488 | ENSP00000357880 | chloride channel, voltage-sensitive 6 | adenosylmethionine decarboxylase 1 | 0.660 |
CLCN6 | CLN6 | ENSP00000234488 | ENSP00000249806 | chloride channel, voltage-sensitive 6 | ceroid-lipofuscinosis, neuronal 6, late infantile, variant | 0.536 |
CLCN6 | MTHFR | ENSP00000234488 | ENSP00000365775 | chloride channel, voltage-sensitive 6 | methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | 0.493 |
CLCN6 | OSTM1 | ENSP00000234488 | ENSP00000193322 | chloride channel, voltage-sensitive 6 | osteopetrosis associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function (By similarity) | 0.590 |
CLCN6 | PPP2R1A | ENSP00000234488 | ENSP00000324804 | chloride channel, voltage-sensitive 6 | protein phosphatase 2, regulatory subunit A, alpha; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis | 0.530 |
CLCN6 | PPT1 | ENSP00000234488 | ENSP00000394863 | chloride channel, voltage-sensitive 6 | palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons | 0.607 |
CLCN6 | TELO2 | ENSP00000234488 | ENSP00000262319 | chloride channel, voltage-sensitive 6 | TEL2, telomere maintenance 2, homolog (S. cerevisiae); Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complex [...] | 0.502 |
CLCN6 | UBC | ENSP00000234488 | ENSP00000344818 | chloride channel, voltage-sensitive 6 | ubiquitin C | 0.645 |
CLCN6 | VEPH1 | ENSP00000234488 | ENSP00000354919 | chloride channel, voltage-sensitive 6 | ventricular zone expressed PH domain homolog 1 (zebrafish) | 0.485 |
CLN6 | CLCN6 | ENSP00000249806 | ENSP00000234488 | ceroid-lipofuscinosis, neuronal 6, late infantile, variant | chloride channel, voltage-sensitive 6 | 0.536 |
CLN6 | PPT1 | ENSP00000249806 | ENSP00000394863 | ceroid-lipofuscinosis, neuronal 6, late infantile, variant | palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons | 0.820 |
CLN6 | UBC | ENSP00000249806 | ENSP00000344818 | ceroid-lipofuscinosis, neuronal 6, late infantile, variant | ubiquitin C | 0.500 |
MTHFR | ABCB1 | ENSP00000365775 | ENSP00000265724 | methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | 0.474 |