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STRINGSTRING
AMD1 AMD1 OSTM1 OSTM1 PPT1 PPT1 CLN6 CLN6 CLCN6 CLCN6 UBC UBC MTHFR MTHFR ABCB1 ABCB1 PPP2R1A PPP2R1A TELO2 TELO2 VEPH1 VEPH1
"CLCN6" - chloride channel, voltage-sensitive 6 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
CLCN6chloride channel, voltage-sensitive 6 (869 aa)    
Predicted Functional Partners:
AMD1
adenosylmethionine decarboxylase 1 (334 aa)
            score_image   0.660
UBC
ubiquitin C (685 aa)
        score_image       0.645
PPT1
palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (306 aa)
            score_image   0.607
OSTM1
osteopetrosis associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function (By similarity) (334 aa)
            score_image   0.590
CLN6
ceroid-lipofuscinosis, neuronal 6, late infantile, variant (311 aa)
            score_image   0.536
PPP2R1A
protein phosphatase 2, regulatory subunit A, alpha; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis (589 aa)
        score_image       0.530
TELO2
TEL2, telomere maintenance 2, homolog (S. cerevisiae); Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complex [...] (837 aa)
            score_image   0.502
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine (656 aa)
            score_image   0.493
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (1280 aa)
            score_image   0.488
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish) (833 aa)
            score_image   0.485
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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