| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AP1M1 | TMEM59 | ENSP00000388996 | ENSP00000234831 | adaptor-related protein complex 1, mu 1 subunit; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding | 0.570 |
| AP1M1 | UBC | ENSP00000388996 | ENSP00000344818 | adaptor-related protein complex 1, mu 1 subunit; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | ubiquitin C | 0.866 |
| ATG16L1 | TMEM59 | ENSP00000375872 | ENSP00000234831 | autophagy related 16-like 1 (S. cerevisiae) | transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding | 0.929 |
| ATG16L1 | UBC | ENSP00000375872 | ENSP00000344818 | autophagy related 16-like 1 (S. cerevisiae) | ubiquitin C | 0.786 |
| EMC6 | TMEM26 | ENSP00000248378 | ENSP00000382237 | ER membrane protein complex subunit 6 | transmembrane protein 26 | 0.622 |
| EMC6 | TMEM43 | ENSP00000248378 | ENSP00000303992 | ER membrane protein complex subunit 6 | transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity) | 0.642 |
| EMC6 | TMEM59 | ENSP00000248378 | ENSP00000234831 | ER membrane protein complex subunit 6 | transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding | 0.627 |
| EMC6 | UBC | ENSP00000248378 | ENSP00000344818 | ER membrane protein complex subunit 6 | ubiquitin C | 0.516 |
| LACE1 | MRPL24 | ENSP00000357973 | ENSP00000354525 | lactation elevated 1 | mitochondrial ribosomal protein L24 | 0.664 |
| LACE1 | MRPS25 | ENSP00000357973 | ENSP00000253686 | lactation elevated 1 | mitochondrial ribosomal protein S25 | 0.630 |
| LACE1 | TMEM59 | ENSP00000357973 | ENSP00000234831 | lactation elevated 1 | transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding | 0.618 |
| LACE1 | ZNF451 | ENSP00000357973 | ENSP00000359740 | lactation elevated 1 | zinc finger protein 451; May be involved in transcriptional regulation. Coactivator for steroid receptors | 0.615 |
| MRPL24 | LACE1 | ENSP00000354525 | ENSP00000357973 | mitochondrial ribosomal protein L24 | lactation elevated 1 | 0.664 |
| MRPL24 | MRPS25 | ENSP00000354525 | ENSP00000253686 | mitochondrial ribosomal protein L24 | mitochondrial ribosomal protein S25 | 0.659 |
| MRPL24 | TMEM59 | ENSP00000354525 | ENSP00000234831 | mitochondrial ribosomal protein L24 | transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding | 0.649 |
| MRPL24 | UBC | ENSP00000354525 | ENSP00000344818 | mitochondrial ribosomal protein L24 | ubiquitin C | 0.553 |
| MRPL24 | ZNF451 | ENSP00000354525 | ENSP00000359740 | mitochondrial ribosomal protein L24 | zinc finger protein 451; May be involved in transcriptional regulation. Coactivator for steroid receptors | 0.636 |
| MRPS25 | LACE1 | ENSP00000253686 | ENSP00000357973 | mitochondrial ribosomal protein S25 | lactation elevated 1 | 0.630 |
| MRPS25 | MRPL24 | ENSP00000253686 | ENSP00000354525 | mitochondrial ribosomal protein S25 | mitochondrial ribosomal protein L24 | 0.659 |
| MRPS25 | TMEM59 | ENSP00000253686 | ENSP00000234831 | mitochondrial ribosomal protein S25 | transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding | 0.625 |
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