node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADRA1A | AGT | ENSP00000369960 | ENSP00000355627 | adrenoceptor alpha 1A | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 0.911 |
ADRA1A | EDN1 | ENSP00000369960 | ENSP00000368683 | adrenoceptor alpha 1A | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | 0.902 |
ADRA1A | F2R | ENSP00000369960 | ENSP00000321326 | adrenoceptor alpha 1A | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | 0.900 |
ADRA1A | GNA11 | ENSP00000369960 | ENSP00000078429 | adrenoceptor alpha 1A | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | 0.957 |
ADRA1A | GNA15 | ENSP00000369960 | ENSP00000262958 | adrenoceptor alpha 1A | guanine nucleotide binding protein (G protein), alpha 15 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.906 |
ADRA1A | GNAQ | ENSP00000369960 | ENSP00000286548 | adrenoceptor alpha 1A | guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity) | 0.961 |
ADRA1A | HTR2A | ENSP00000369960 | ENSP00000367959 | adrenoceptor alpha 1A | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production | 0.906 |
ADRA1A | RGS2 | ENSP00000369960 | ENSP00000235382 | adrenoceptor alpha 1A | regulator of G-protein signaling 2, 24kDa; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein | 0.961 |
AGT | ADRA1A | ENSP00000355627 | ENSP00000369960 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | adrenoceptor alpha 1A | 0.911 |
AGT | EDN1 | ENSP00000355627 | ENSP00000368683 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | 0.968 |
AGT | F2R | ENSP00000355627 | ENSP00000321326 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | 0.916 |
AGT | GNA11 | ENSP00000355627 | ENSP00000078429 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | 0.928 |
AGT | GNA15 | ENSP00000355627 | ENSP00000262958 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | guanine nucleotide binding protein (G protein), alpha 15 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.923 |
AGT | GNAI3 | ENSP00000355627 | ENSP00000358867 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division | 0.900 |
AGT | GNAQ | ENSP00000355627 | ENSP00000286548 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity) | 0.925 |
AGT | HTR2A | ENSP00000355627 | ENSP00000367959 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production | 0.910 |
AGT | RGS2 | ENSP00000355627 | ENSP00000235382 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | regulator of G-protein signaling 2, 24kDa; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein | 0.980 |
EDN1 | ADRA1A | ENSP00000368683 | ENSP00000369960 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | adrenoceptor alpha 1A | 0.902 |
EDN1 | AGT | ENSP00000368683 | ENSP00000355627 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 0.968 |
EDN1 | F2R | ENSP00000368683 | ENSP00000321326 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | 0.948 |