WARS2 protein (Homo sapiens) - STRING network view

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Score

WARS2

tryptophanyl tRNA synthetase 2, mitochondrial (360 aa)

Predicted Functional Partners:

WARS

0.980

FARS2

0.961

YARS

0.934

YARS2

0.923

IARS2

0.890

RARS2

0.888

MARS2

0.888

MARS

0.886

FARSB

0.845

TARS2

0.843

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FARS2	FARSB	ENSP00000274680	ENSP00000281828	phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins	phenylalanyl-tRNA synthetase, beta subunit	0.988
FARS2	IARS2	ENSP00000274680	ENSP00000303279	phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins	isoleucyl-tRNA synthetase 2, mitochondrial	0.970
FARS2	MARS	ENSP00000274680	ENSP00000262027	phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins	methionyl-tRNA synthetase	0.947
FARS2	MARS2	ENSP00000274680	ENSP00000282276	phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins	methionyl-tRNA synthetase 2, mitochondrial	0.948
FARS2	RARS2	ENSP00000274680	ENSP00000358549	phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins	arginyl-tRNA synthetase 2, mitochondrial	0.915
FARS2	TARS2	ENSP00000274680	ENSP00000358060	phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins	threonyl-tRNA synthetase 2, mitochondrial (putative)	0.973
FARS2	WARS	ENSP00000274680	ENSP00000347495	phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins	tryptophanyl-tRNA synthetase; Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression	0.904
FARS2	WARS2	ENSP00000274680	ENSP00000235521	phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins	tryptophanyl tRNA synthetase 2, mitochondrial	0.961
FARS2	YARS	ENSP00000274680	ENSP00000362576	phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins	tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)	0.995
FARS2	YARS2	ENSP00000274680	ENSP00000320658	phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins	tyrosyl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)	0.951
FARSB	FARS2	ENSP00000281828	ENSP00000274680	phenylalanyl-tRNA synthetase, beta subunit	phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins	0.988
FARSB	IARS2	ENSP00000281828	ENSP00000303279	phenylalanyl-tRNA synthetase, beta subunit	isoleucyl-tRNA synthetase 2, mitochondrial	0.879
FARSB	MARS	ENSP00000281828	ENSP00000262027	phenylalanyl-tRNA synthetase, beta subunit	methionyl-tRNA synthetase	0.928
FARSB	MARS2	ENSP00000281828	ENSP00000282276	phenylalanyl-tRNA synthetase, beta subunit	methionyl-tRNA synthetase 2, mitochondrial	0.821
FARSB	RARS2	ENSP00000281828	ENSP00000358549	phenylalanyl-tRNA synthetase, beta subunit	arginyl-tRNA synthetase 2, mitochondrial	0.836
FARSB	TARS2	ENSP00000281828	ENSP00000358060	phenylalanyl-tRNA synthetase, beta subunit	threonyl-tRNA synthetase 2, mitochondrial (putative)	0.927
FARSB	WARS	ENSP00000281828	ENSP00000347495	phenylalanyl-tRNA synthetase, beta subunit	tryptophanyl-tRNA synthetase; Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression	0.853
FARSB	WARS2	ENSP00000281828	ENSP00000235521	phenylalanyl-tRNA synthetase, beta subunit	tryptophanyl tRNA synthetase 2, mitochondrial	0.845
FARSB	YARS	ENSP00000281828	ENSP00000362576	phenylalanyl-tRNA synthetase, beta subunit	tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)	0.930
FARSB	YARS2	ENSP00000281828	ENSP00000320658	phenylalanyl-tRNA synthetase, beta subunit	tyrosyl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)	0.824

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