NT5C1A protein (Homo sapiens) - STRING network view

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NT5C1A

5’-nucleotidase, cytosolic IA; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia (368 aa)

Predicted Functional Partners:

AMPD1

0.946

ADK

0.921

AMPD2

0.917

DCK

0.916

AMPD3

0.916

DCTD

0.916

PDE4D

0.915

CDA

0.911

PDE4C

0.910

PDE4B

0.910

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADK	AMPD1	ENSP00000286621	ENSP00000430075	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism	0.962
ADK	AMPD2	ENSP00000286621	ENSP00000256578	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	adenosine monophosphate deaminase 2	0.964
ADK	AMPD3	ENSP00000286621	ENSP00000379802	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	adenosine monophosphate deaminase 3; AMP deaminase plays a critical role in energy metabolism	0.969
ADK	DCK	ENSP00000286621	ENSP00000286648	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents	0.705
ADK	NT5C1A	ENSP00000286621	ENSP00000235628	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	5’-nucleotidase, cytosolic IA; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia	0.921
ADK	PDE4B	ENSP00000286621	ENSP00000332116	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	phosphodiesterase 4B, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents	0.902
ADK	PDE4C	ENSP00000286621	ENSP00000347689	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	phosphodiesterase 4C, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes	0.902
ADK	PDE4D	ENSP00000286621	ENSP00000345502	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	phosphodiesterase 4D, cAMP-specific	0.902
AMPD1	ADK	ENSP00000430075	ENSP00000286621	adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	0.962
AMPD1	DCK	ENSP00000430075	ENSP00000286648	adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism	deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents	0.900
AMPD1	NT5C1A	ENSP00000430075	ENSP00000235628	adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism	5’-nucleotidase, cytosolic IA; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia	0.946
AMPD1	PDE4B	ENSP00000430075	ENSP00000332116	adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism	phosphodiesterase 4B, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents	0.900
AMPD1	PDE4C	ENSP00000430075	ENSP00000347689	adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism	phosphodiesterase 4C, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes	0.900
AMPD1	PDE4D	ENSP00000430075	ENSP00000345502	adenosine monophosphate deaminase 1; AMP deaminase plays a critical role in energy metabolism	phosphodiesterase 4D, cAMP-specific	0.900
AMPD2	ADK	ENSP00000256578	ENSP00000286621	adenosine monophosphate deaminase 2	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	0.964
AMPD2	DCK	ENSP00000256578	ENSP00000286648	adenosine monophosphate deaminase 2	deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents	0.900
AMPD2	DCTD	ENSP00000256578	ENSP00000349576	adenosine monophosphate deaminase 2	dCMP deaminase; Supplies the nucleotide substrate for thymidylate synthetase	0.493
AMPD2	NT5C1A	ENSP00000256578	ENSP00000235628	adenosine monophosphate deaminase 2	5’-nucleotidase, cytosolic IA; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia	0.917
AMPD2	PDE4B	ENSP00000256578	ENSP00000332116	adenosine monophosphate deaminase 2	phosphodiesterase 4B, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents	0.900
AMPD2	PDE4C	ENSP00000256578	ENSP00000347689	adenosine monophosphate deaminase 2	phosphodiesterase 4C, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes	0.900

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