CD160 protein (Homo sapiens) - STRING network view

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CD160

CD160 molecule; Receptor showing broad specificity for both classical and non-classical MHC class I molecules (181 aa)

Predicted Functional Partners:

HLA-C

0.820

NCAM1

0.580

MDM4

0.557

ITGAM

0.510

TNFRSF14

0.401

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD160	HLA-C	ENSP00000235933	ENSP00000365402	CD160 molecule; Receptor showing broad specificity for both classical and non-classical MHC class I molecules	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.820
CD160	ITGAM	ENSP00000235933	ENSP00000441691	CD160 molecule; Receptor showing broad specificity for both classical and non-classical MHC class I molecules	integrin, alpha M (complement component 3 receptor 3 subunit); Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain	0.510
CD160	MDM4	ENSP00000235933	ENSP00000356150	CD160 molecule; Receptor showing broad specificity for both classical and non-classical MHC class I molecules	Mdm4 p53 binding protein homolog (mouse); Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions	0.557
CD160	NCAM1	ENSP00000235933	ENSP00000318472	CD160 molecule; Receptor showing broad specificity for both classical and non-classical MHC class I molecules	neural cell adhesion molecule 1	0.580
CD160	TNFRSF14	ENSP00000235933	ENSP00000347948	CD160 molecule; Receptor showing broad specificity for both classical and non-classical MHC class I molecules	tumor necrosis factor receptor superfamily, member 14; Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells	0.401
HLA-C	CD160	ENSP00000365402	ENSP00000235933	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	CD160 molecule; Receptor showing broad specificity for both classical and non-classical MHC class I molecules	0.820
HLA-C	NCAM1	ENSP00000365402	ENSP00000318472	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	neural cell adhesion molecule 1	0.954
ITGAM	CD160	ENSP00000441691	ENSP00000235933	integrin, alpha M (complement component 3 receptor 3 subunit); Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain	CD160 molecule; Receptor showing broad specificity for both classical and non-classical MHC class I molecules	0.510
ITGAM	NCAM1	ENSP00000441691	ENSP00000318472	integrin, alpha M (complement component 3 receptor 3 subunit); Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain	neural cell adhesion molecule 1	0.725
MDM4	CD160	ENSP00000356150	ENSP00000235933	Mdm4 p53 binding protein homolog (mouse); Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions	CD160 molecule; Receptor showing broad specificity for both classical and non-classical MHC class I molecules	0.557
NCAM1	CD160	ENSP00000318472	ENSP00000235933	neural cell adhesion molecule 1	CD160 molecule; Receptor showing broad specificity for both classical and non-classical MHC class I molecules	0.580
NCAM1	HLA-C	ENSP00000318472	ENSP00000365402	neural cell adhesion molecule 1	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.954
NCAM1	ITGAM	ENSP00000318472	ENSP00000441691	neural cell adhesion molecule 1	integrin, alpha M (complement component 3 receptor 3 subunit); Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain	0.725
TNFRSF14	CD160	ENSP00000347948	ENSP00000235933	tumor necrosis factor receptor superfamily, member 14; Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells	CD160 molecule; Receptor showing broad specificity for both classical and non-classical MHC class I molecules	0.401

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