node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTD | SLC19A2 | ENSP00000306477 | ENSP00000236137 | biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation | solute carrier family 19 (thiamine transporter), member 2; High-affinity transporter for the intake of thiamine | 0.513 |
BTD | SLC5A6 | ENSP00000306477 | ENSP00000310208 | biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation | solute carrier family 5 (sodium-dependent vitamin transporter), member 6; Transports pantothenate, biotin and lipoate in the presence of sodium | 0.602 |
FLVCR1 | SLC19A2 | ENSP00000355938 | ENSP00000236137 | feline leukemia virus subgroup C cellular receptor 1; Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro | solute carrier family 19 (thiamine transporter), member 2; High-affinity transporter for the intake of thiamine | 0.698 |
FLVCR1 | UBC | ENSP00000355938 | ENSP00000344818 | feline leukemia virus subgroup C cellular receptor 1; Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro | ubiquitin C | 0.862 |
FLVCR2 | SLC19A2 | ENSP00000238667 | ENSP00000236137 | feline leukemia virus subgroup C cellular receptor family, member 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism | solute carrier family 19 (thiamine transporter), member 2; High-affinity transporter for the intake of thiamine | 0.559 |
PUS1 | SLC19A2 | ENSP00000365837 | ENSP00000236137 | pseudouridylate synthase 1; Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (By similarity) | solute carrier family 19 (thiamine transporter), member 2; High-affinity transporter for the intake of thiamine | 0.581 |
PUS1 | UBC | ENSP00000365837 | ENSP00000344818 | pseudouridylate synthase 1; Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (By similarity) | ubiquitin C | 0.551 |
SLC19A2 | BTD | ENSP00000236137 | ENSP00000306477 | solute carrier family 19 (thiamine transporter), member 2; High-affinity transporter for the intake of thiamine | biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation | 0.513 |
SLC19A2 | FLVCR1 | ENSP00000236137 | ENSP00000355938 | solute carrier family 19 (thiamine transporter), member 2; High-affinity transporter for the intake of thiamine | feline leukemia virus subgroup C cellular receptor 1; Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro | 0.698 |
SLC19A2 | FLVCR2 | ENSP00000236137 | ENSP00000238667 | solute carrier family 19 (thiamine transporter), member 2; High-affinity transporter for the intake of thiamine | feline leukemia virus subgroup C cellular receptor family, member 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism | 0.559 |
SLC19A2 | PUS1 | ENSP00000236137 | ENSP00000365837 | solute carrier family 19 (thiamine transporter), member 2; High-affinity transporter for the intake of thiamine | pseudouridylate synthase 1; Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (By similarity) | 0.581 |
SLC19A2 | SLC5A6 | ENSP00000236137 | ENSP00000310208 | solute carrier family 19 (thiamine transporter), member 2; High-affinity transporter for the intake of thiamine | solute carrier family 5 (sodium-dependent vitamin transporter), member 6; Transports pantothenate, biotin and lipoate in the presence of sodium | 0.474 |
SLC19A2 | TKT | ENSP00000236137 | ENSP00000405455 | solute carrier family 19 (thiamine transporter), member 2; High-affinity transporter for the intake of thiamine | transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate | 0.507 |
SLC19A2 | TP53 | ENSP00000236137 | ENSP00000269305 | solute carrier family 19 (thiamine transporter), member 2; High-affinity transporter for the intake of thiamine | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.787 |
SLC19A2 | TPK1 | ENSP00000236137 | ENSP00000353165 | solute carrier family 19 (thiamine transporter), member 2; High-affinity transporter for the intake of thiamine | thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate | 0.928 |
SLC19A2 | TSPAN1 | ENSP00000236137 | ENSP00000361072 | solute carrier family 19 (thiamine transporter), member 2; High-affinity transporter for the intake of thiamine | tetraspanin 1 | 0.804 |
SLC19A2 | UBC | ENSP00000236137 | ENSP00000344818 | solute carrier family 19 (thiamine transporter), member 2; High-affinity transporter for the intake of thiamine | ubiquitin C | 0.620 |
SLC5A6 | BTD | ENSP00000310208 | ENSP00000306477 | solute carrier family 5 (sodium-dependent vitamin transporter), member 6; Transports pantothenate, biotin and lipoate in the presence of sodium | biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation | 0.602 |
SLC5A6 | SLC19A2 | ENSP00000310208 | ENSP00000236137 | solute carrier family 5 (sodium-dependent vitamin transporter), member 6; Transports pantothenate, biotin and lipoate in the presence of sodium | solute carrier family 19 (thiamine transporter), member 2; High-affinity transporter for the intake of thiamine | 0.474 |
SLC5A6 | UBC | ENSP00000310208 | ENSP00000344818 | solute carrier family 5 (sodium-dependent vitamin transporter), member 6; Transports pantothenate, biotin and lipoate in the presence of sodium | ubiquitin C | 0.849 |