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STRINGSTRING
LCAT LCAT CETP CETP APOA2 APOA2 APOB APOB ABCA1 ABCA1 APOC3 APOC3 APOE APOE APOA1 APOA1 HNF4A HNF4A TTR TTR FGA FGA
"APOA1" - apolipoprotein A-I in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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experimentally determined
Predicted Interactions
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gene co-occurrence
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protein homology
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APOA1apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (267 aa)    
Predicted Functional Partners:
LCAT
lecithin-cholesterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16-0-18-2 or 18-O-18-2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-contain [...] (440 aa)
      score_image score_image score_image score_image   0.999
APOB
apolipoprotein B (including Ag(x) antigen) (4563 aa)
      score_image score_image score_image score_image   0.999
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1 (2261 aa)
        score_image score_image score_image   0.999
APOA2
apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism (100 aa)
        score_image score_image score_image   0.997
APOE
apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues (317 aa)
      score_image score_image score_image score_image   0.991
HNF4A
hepatocyte nuclear factor 4, alpha (474 aa)
      score_image   score_image score_image   0.989
APOC3
apolipoprotein C-III; Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles (99 aa)
      score_image score_image score_image score_image   0.987
CETP
cholesteryl ester transfer protein, plasma; Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol (493 aa)
        score_image score_image score_image   0.987
TTR
transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (147 aa)
      score_image score_image score_image score_image   0.986
FGA
fibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation (866 aa)
      score_image score_image score_image score_image   0.983
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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