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HIST1H1T HIST1H1T PGK2 PGK2 PRM1 PRM1 VIL1 VIL1 PRM2 PRM2 TNP1 TNP1 TNP2 TNP2 PPARA PPARA KPNA3 KPNA3 KDM3A KDM3A PPARG PPARG
"TNP1" - transition protein 1 (during histone to protamine replacement) in Homo sapiens
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TNP1transition protein 1 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (55 aa)    
Predicted Functional Partners:
TNP2
transition protein 2 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (By similarity) (138 aa)
            score_image   0.870
PRM1
protamine 1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) (51 aa)
            score_image   0.824
PRM2
protamine 2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (102 aa)
            score_image   0.816
KDM3A
lysine (K)-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activa [...] (1321 aa)
            score_image   0.753
VIL1
villin 1; Epithelial cell-specific Ca(2+)-regulated actin- modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the int [...] (827 aa)
            score_image   0.743
HIST1H1T
histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures (207 aa)
            score_image   0.700
PPARA
peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16-0/18-1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerizati [...] (468 aa)
        score_image   score_image   0.677
PPARG
peroxisome proliferator-activated receptor gamma (505 aa)
        score_image   score_image   0.649
PGK2
phosphoglycerate kinase 2 (417 aa)
            score_image   0.631
KPNA3
karyopherin alpha 3 (importin alpha 4); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...] (521 aa)
            score_image   0.610
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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