node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HIST1H1T | PGK2 | ENSP00000341214 | ENSP00000305995 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | phosphoglycerate kinase 2 | 0.562 |
HIST1H1T | PRM1 | ENSP00000341214 | ENSP00000310515 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | protamine 1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | 0.637 |
HIST1H1T | PRM2 | ENSP00000341214 | ENSP00000241808 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | protamine 2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex | 0.633 |
HIST1H1T | TNP1 | ENSP00000341214 | ENSP00000236979 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | transition protein 1 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins | 0.700 |
HIST1H1T | TNP2 | ENSP00000341214 | ENSP00000325738 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | transition protein 2 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (By similarity) | 0.645 |
KDM3A | PPARA | ENSP00000323659 | ENSP00000262735 | lysine (K)-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activa [...] | peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16-0/18-1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerizati [...] | 0.609 |
KDM3A | PPARG | ENSP00000323659 | ENSP00000287820 | lysine (K)-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activa [...] | peroxisome proliferator-activated receptor gamma | 0.440 |
KDM3A | PRM1 | ENSP00000323659 | ENSP00000310515 | lysine (K)-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activa [...] | protamine 1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | 0.817 |
KDM3A | PRM2 | ENSP00000323659 | ENSP00000241808 | lysine (K)-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activa [...] | protamine 2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex | 0.607 |
KDM3A | TNP1 | ENSP00000323659 | ENSP00000236979 | lysine (K)-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activa [...] | transition protein 1 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins | 0.753 |
KDM3A | TNP2 | ENSP00000323659 | ENSP00000325738 | lysine (K)-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activa [...] | transition protein 2 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (By similarity) | 0.610 |
KPNA3 | TNP1 | ENSP00000261667 | ENSP00000236979 | karyopherin alpha 3 (importin alpha 4); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...] | transition protein 1 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins | 0.610 |
KPNA3 | TNP2 | ENSP00000261667 | ENSP00000325738 | karyopherin alpha 3 (importin alpha 4); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...] | transition protein 2 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (By similarity) | 0.755 |
PGK2 | HIST1H1T | ENSP00000305995 | ENSP00000341214 | phosphoglycerate kinase 2 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | 0.562 |
PGK2 | PRM1 | ENSP00000305995 | ENSP00000310515 | phosphoglycerate kinase 2 | protamine 1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | 0.725 |
PGK2 | PRM2 | ENSP00000305995 | ENSP00000241808 | phosphoglycerate kinase 2 | protamine 2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex | 0.725 |
PGK2 | TNP1 | ENSP00000305995 | ENSP00000236979 | phosphoglycerate kinase 2 | transition protein 1 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins | 0.631 |
PGK2 | TNP2 | ENSP00000305995 | ENSP00000325738 | phosphoglycerate kinase 2 | transition protein 2 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (By similarity) | 0.691 |
PPARA | KDM3A | ENSP00000262735 | ENSP00000323659 | peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16-0/18-1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerizati [...] | lysine (K)-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activa [...] | 0.609 |
PPARA | PPARG | ENSP00000262735 | ENSP00000287820 | peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16-0/18-1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerizati [...] | peroxisome proliferator-activated receptor gamma | 0.903 |