| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AOX1 | GDA | ENSP00000363832 | ENSP00000238018 | aldehyde oxidase 1 | guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity) | 0.728 |
| AOX1 | XDH | ENSP00000363832 | ENSP00000368727 | aldehyde oxidase 1 | xanthine dehydrogenase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro) | 0.945 |
| APRT | GDA | ENSP00000367615 | ENSP00000238018 | adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity) | 0.945 |
| APRT | HPRT1 | ENSP00000367615 | ENSP00000298556 | adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | hypoxanthine phosphoribosyltransferase 1; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway | 0.985 |
| APRT | PNP | ENSP00000367615 | ENSP00000354532 | adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) | 0.932 |
| BDNF | DLG4 | ENSP00000414303 | ENSP00000293813 | brain-derived neurotrophic factor | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.472 |
| BDNF | GDA | ENSP00000414303 | ENSP00000238018 | brain-derived neurotrophic factor | guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity) | 0.831 |
| BDNF | RHOA | ENSP00000414303 | ENSP00000400175 | brain-derived neurotrophic factor | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.503 |
| DLG1 | DLG3 | ENSP00000345731 | ENSP00000363480 | discs, large homolog 1 (Drosophila) | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | 0.955 |
| DLG1 | DLG4 | ENSP00000345731 | ENSP00000293813 | discs, large homolog 1 (Drosophila) | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.956 |
| DLG1 | GDA | ENSP00000345731 | ENSP00000238018 | discs, large homolog 1 (Drosophila) | guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity) | 0.895 |
| DLG1 | RHOA | ENSP00000345731 | ENSP00000400175 | discs, large homolog 1 (Drosophila) | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.441 |
| DLG3 | DLG1 | ENSP00000363480 | ENSP00000345731 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | discs, large homolog 1 (Drosophila) | 0.955 |
| DLG3 | DLG4 | ENSP00000363480 | ENSP00000293813 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.956 |
| DLG3 | GDA | ENSP00000363480 | ENSP00000238018 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity) | 0.953 |
| DLG3 | RHOA | ENSP00000363480 | ENSP00000400175 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.473 |
| DLG4 | BDNF | ENSP00000293813 | ENSP00000414303 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | brain-derived neurotrophic factor | 0.472 |
| DLG4 | DLG1 | ENSP00000293813 | ENSP00000345731 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | discs, large homolog 1 (Drosophila) | 0.956 |
| DLG4 | DLG3 | ENSP00000293813 | ENSP00000363480 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | 0.956 |
| DLG4 | GDA | ENSP00000293813 | ENSP00000238018 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity) | 0.831 |
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