node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSE1L | TP53 | ENSP00000262982 | ENSP00000269305 | CSE1 chromosome segregation 1-like (yeast) | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.709 |
CSE1L | TP53I3 | ENSP00000262982 | ENSP00000238721 | CSE1 chromosome segregation 1-like (yeast) | tumor protein p53 inducible protein 3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro) | 0.955 |
ICT1 | MRPL13 | ENSP00000301585 | ENSP00000306548 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L13 | 0.903 |
ICT1 | MRPL23 | ENSP00000301585 | ENSP00000370930 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L23 | 0.951 |
ICT1 | MRPL3 | ENSP00000301585 | ENSP00000264995 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L3 | 0.986 |
ICT1 | MRPL42 | ENSP00000301585 | ENSP00000447547 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L42 | 0.903 |
ICT1 | MRPL55 | ENSP00000301585 | ENSP00000355692 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L55 | 0.938 |
ICT1 | TP53I3 | ENSP00000301585 | ENSP00000238721 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | tumor protein p53 inducible protein 3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro) | 0.922 |
MRPL13 | ICT1 | ENSP00000306548 | ENSP00000301585 | mitochondrial ribosomal protein L13 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | 0.903 |
MRPL13 | MRPL23 | ENSP00000306548 | ENSP00000370930 | mitochondrial ribosomal protein L13 | mitochondrial ribosomal protein L23 | 0.979 |
MRPL13 | MRPL3 | ENSP00000306548 | ENSP00000264995 | mitochondrial ribosomal protein L13 | mitochondrial ribosomal protein L3 | 0.999 |
MRPL13 | MRPL42 | ENSP00000306548 | ENSP00000447547 | mitochondrial ribosomal protein L13 | mitochondrial ribosomal protein L42 | 0.913 |
MRPL13 | MRPL55 | ENSP00000306548 | ENSP00000355692 | mitochondrial ribosomal protein L13 | mitochondrial ribosomal protein L55 | 0.938 |
MRPL13 | TP53I3 | ENSP00000306548 | ENSP00000238721 | mitochondrial ribosomal protein L13 | tumor protein p53 inducible protein 3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro) | 0.905 |
MRPL23 | ICT1 | ENSP00000370930 | ENSP00000301585 | mitochondrial ribosomal protein L23 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | 0.951 |
MRPL23 | MRPL13 | ENSP00000370930 | ENSP00000306548 | mitochondrial ribosomal protein L23 | mitochondrial ribosomal protein L13 | 0.979 |
MRPL23 | MRPL3 | ENSP00000370930 | ENSP00000264995 | mitochondrial ribosomal protein L23 | mitochondrial ribosomal protein L3 | 0.984 |
MRPL23 | MRPL42 | ENSP00000370930 | ENSP00000447547 | mitochondrial ribosomal protein L23 | mitochondrial ribosomal protein L42 | 0.901 |
MRPL23 | MRPL55 | ENSP00000370930 | ENSP00000355692 | mitochondrial ribosomal protein L23 | mitochondrial ribosomal protein L55 | 0.962 |
MRPL23 | TP53I3 | ENSP00000370930 | ENSP00000238721 | mitochondrial ribosomal protein L23 | tumor protein p53 inducible protein 3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro) | 0.909 |