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STRINGSTRING
TMED7 TMED7 SEC31A SEC31A SEC31B SEC31B AP2A1 AP2A1 AP2M1 AP2M1 AFTPH AFTPH SCYL1 SCYL1 AP1S1 AP1S1 AP1G2 AP1G2 AP5B1 AP5B1 AP3S2 AP3S2
"AFTPH" - aftiphilin in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFTPHaftiphilin; May play a role in membrane trafficking (936 aa)    
Predicted Functional Partners:
AP1G2
adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV) (785 aa)
        score_image score_image score_image   0.958
SCYL1
SCY1-like 1 (S. cerevisiae); Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro (808 aa)
          score_image score_image   0.910
AP2M1
adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...] (435 aa)
          score_image score_image   0.900
AP5B1
adaptor-related protein complex 5, beta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport (878 aa)
          score_image     0.900
TMED7
transmembrane emp24 protein transport domain containing 7; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post- translational modifications (224 aa)
          score_image     0.900
SEC31B
SEC31 homolog B (S. cerevisiae); As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum (1179 aa)
          score_image     0.900
AP2A1
adaptor-related protein complex 2, alpha 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] (977 aa)
          score_image     0.900
SEC31A
SEC31 homolog A (S. cerevisiae) (1220 aa)
          score_image     0.900
AP3S2
adaptor-related protein complex 3, sigma 2 subunit; Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (193 aa)
          score_image     0.900
AP1S1
adaptor-related protein complex 1, sigma 1 subunit; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (158 aa)
          score_image     0.900
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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