node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFTPH | AP1G2 | ENSP00000238855 | ENSP00000312442 | aftiphilin; May play a role in membrane trafficking | adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV) | 0.958 |
AFTPH | AP1S1 | ENSP00000238855 | ENSP00000336666 | aftiphilin; May play a role in membrane trafficking | adaptor-related protein complex 1, sigma 1 subunit; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | 0.900 |
AFTPH | AP2A1 | ENSP00000238855 | ENSP00000351926 | aftiphilin; May play a role in membrane trafficking | adaptor-related protein complex 2, alpha 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] | 0.900 |
AFTPH | AP2M1 | ENSP00000238855 | ENSP00000292807 | aftiphilin; May play a role in membrane trafficking | adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...] | 0.900 |
AFTPH | AP3S2 | ENSP00000238855 | ENSP00000338777 | aftiphilin; May play a role in membrane trafficking | adaptor-related protein complex 3, sigma 2 subunit; Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals | 0.900 |
AFTPH | AP5B1 | ENSP00000238855 | ENSP00000454303 | aftiphilin; May play a role in membrane trafficking | adaptor-related protein complex 5, beta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport | 0.900 |
AFTPH | SCYL1 | ENSP00000238855 | ENSP00000270176 | aftiphilin; May play a role in membrane trafficking | SCY1-like 1 (S. cerevisiae); Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro | 0.910 |
AFTPH | SEC31A | ENSP00000238855 | ENSP00000347329 | aftiphilin; May play a role in membrane trafficking | SEC31 homolog A (S. cerevisiae) | 0.900 |
AFTPH | SEC31B | ENSP00000238855 | ENSP00000359370 | aftiphilin; May play a role in membrane trafficking | SEC31 homolog B (S. cerevisiae); As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum | 0.900 |
AFTPH | TMED7 | ENSP00000238855 | ENSP00000405926 | aftiphilin; May play a role in membrane trafficking | transmembrane emp24 protein transport domain containing 7; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post- translational modifications | 0.900 |
AP1G2 | AFTPH | ENSP00000312442 | ENSP00000238855 | adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV) | aftiphilin; May play a role in membrane trafficking | 0.958 |
AP1G2 | AP1S1 | ENSP00000312442 | ENSP00000336666 | adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV) | adaptor-related protein complex 1, sigma 1 subunit; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | 0.995 |
AP1G2 | AP2A1 | ENSP00000312442 | ENSP00000351926 | adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV) | adaptor-related protein complex 2, alpha 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] | 0.914 |
AP1G2 | AP2M1 | ENSP00000312442 | ENSP00000292807 | adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV) | adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...] | 0.978 |
AP1G2 | AP3S2 | ENSP00000312442 | ENSP00000338777 | adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV) | adaptor-related protein complex 3, sigma 2 subunit; Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals | 0.941 |
AP1G2 | AP5B1 | ENSP00000312442 | ENSP00000454303 | adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV) | adaptor-related protein complex 5, beta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport | 0.900 |
AP1G2 | SCYL1 | ENSP00000312442 | ENSP00000270176 | adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV) | SCY1-like 1 (S. cerevisiae); Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro | 0.900 |
AP1G2 | SEC31A | ENSP00000312442 | ENSP00000347329 | adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV) | SEC31 homolog A (S. cerevisiae) | 0.903 |
AP1G2 | SEC31B | ENSP00000312442 | ENSP00000359370 | adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV) | SEC31 homolog B (S. cerevisiae); As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum | 0.903 |
AP1G2 | TMED7 | ENSP00000312442 | ENSP00000405926 | adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV) | transmembrane emp24 protein transport domain containing 7; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post- translational modifications | 0.900 |