splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes: protein of unknown 3D structure
large nodes: some 3D structure is known or predicted
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C10orf95
chromosome 10 open reading frame 95 (257 aa)
Predicted Functional Partners:
NUS1
nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (293 aa)
0.576
DCAF16
DDB1 and CUL4 associated factor 16; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (216 aa)
0.406
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606 Other names: H. sapiens, Homo, Homo sapiens, human, man
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
C10orf95
DCAF16
ENSP00000239125
ENSP00000371682
chromosome 10 open reading frame 95
DDB1 and CUL4 associated factor 16; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex
0.406
C10orf95
NUS1
ENSP00000239125
ENSP00000357480
chromosome 10 open reading frame 95
nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol
0.576
DCAF16
C10orf95
ENSP00000371682
ENSP00000239125
DDB1 and CUL4 associated factor 16; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex
chromosome 10 open reading frame 95
0.406
NUS1
C10orf95
ENSP00000357480
ENSP00000239125
nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol
Groups of genes that are frequently observed in each other's genomic neighborhood.
Databases
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Fusion
Genes that are sometimes fused into single open reading frames.
Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
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Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: