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STRINGSTRING
MTHFR MTHFR ZBTB20 ZBTB20 SAP18 SAP18 CCNH CCNH FAM71D FAM71D KIAA1430 KIAA1430 CCDC170 CCDC170 TOX3 TOX3 ESR2 ESR2 FLJ42280 FLJ42280 ZBTB40 ZBTB40
"CCDC170" - coiled-coil domain containing 170 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
CCDC170coiled-coil domain containing 170 (715 aa)    
Predicted Functional Partners:
ZBTB40
zinc finger and BTB domain containing 40; May be involved in transcriptional regulation (1239 aa)
            score_image   0.640
ZBTB20
zinc finger and BTB domain containing 20; May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (741 aa)
            score_image   0.618
CCNH
cyclin H; Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout [...] (323 aa)
        score_image       0.590
FLJ42280
chromosome 7 open reading frame 76 (128 aa)
            score_image   0.562
FAM71D
family with sequence similarity 71, member D (422 aa)
            score_image   0.535
KIAA1430
KIAA1430 (532 aa)
            score_image   0.502
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine (656 aa)
            score_image   0.492
ESR2
estrogen receptor 2 (ER beta) (530 aa)
            score_image   0.483
TOX3
TOX high mobility group box family member 3; Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region (576 aa)
            score_image   0.472
SAP18
Sin3A-associated protein, 18kDa; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent [...] (172 aa)
            score_image   0.452
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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