node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC170 | CCNH | ENSP00000239374 | ENSP00000256897 | coiled-coil domain containing 170 | cyclin H; Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout [...] | 0.590 |
CCDC170 | ESR2 | ENSP00000239374 | ENSP00000343925 | coiled-coil domain containing 170 | estrogen receptor 2 (ER beta) | 0.483 |
CCDC170 | FAM71D | ENSP00000239374 | ENSP00000431905 | coiled-coil domain containing 170 | family with sequence similarity 71, member D | 0.535 |
CCDC170 | FLJ42280 | ENSP00000239374 | ENSP00000349114 | coiled-coil domain containing 170 | chromosome 7 open reading frame 76 | 0.562 |
CCDC170 | KIAA1430 | ENSP00000239374 | ENSP00000409964 | coiled-coil domain containing 170 | KIAA1430 | 0.502 |
CCDC170 | MTHFR | ENSP00000239374 | ENSP00000365775 | coiled-coil domain containing 170 | methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | 0.492 |
CCDC170 | SAP18 | ENSP00000239374 | ENSP00000371973 | coiled-coil domain containing 170 | Sin3A-associated protein, 18kDa; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent [...] | 0.452 |
CCDC170 | TOX3 | ENSP00000239374 | ENSP00000219746 | coiled-coil domain containing 170 | TOX high mobility group box family member 3; Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region | 0.472 |
CCDC170 | ZBTB20 | ENSP00000239374 | ENSP00000419153 | coiled-coil domain containing 170 | zinc finger and BTB domain containing 20; May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses | 0.618 |
CCDC170 | ZBTB40 | ENSP00000239374 | ENSP00000364798 | coiled-coil domain containing 170 | zinc finger and BTB domain containing 40; May be involved in transcriptional regulation | 0.640 |
CCNH | CCDC170 | ENSP00000256897 | ENSP00000239374 | cyclin H; Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout [...] | coiled-coil domain containing 170 | 0.590 |
ESR2 | CCDC170 | ENSP00000343925 | ENSP00000239374 | estrogen receptor 2 (ER beta) | coiled-coil domain containing 170 | 0.483 |
FAM71D | CCDC170 | ENSP00000431905 | ENSP00000239374 | family with sequence similarity 71, member D | coiled-coil domain containing 170 | 0.535 |
FLJ42280 | CCDC170 | ENSP00000349114 | ENSP00000239374 | chromosome 7 open reading frame 76 | coiled-coil domain containing 170 | 0.562 |
FLJ42280 | ZBTB40 | ENSP00000349114 | ENSP00000364798 | chromosome 7 open reading frame 76 | zinc finger and BTB domain containing 40; May be involved in transcriptional regulation | 0.581 |
KIAA1430 | CCDC170 | ENSP00000409964 | ENSP00000239374 | KIAA1430 | coiled-coil domain containing 170 | 0.502 |
MTHFR | CCDC170 | ENSP00000365775 | ENSP00000239374 | methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | coiled-coil domain containing 170 | 0.492 |
SAP18 | CCDC170 | ENSP00000371973 | ENSP00000239374 | Sin3A-associated protein, 18kDa; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent [...] | coiled-coil domain containing 170 | 0.452 |
TOX3 | CCDC170 | ENSP00000219746 | ENSP00000239374 | TOX high mobility group box family member 3; Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region | coiled-coil domain containing 170 | 0.472 |
ZBTB20 | CCDC170 | ENSP00000419153 | ENSP00000239374 | zinc finger and BTB domain containing 20; May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses | coiled-coil domain containing 170 | 0.618 |