splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes: protein of unknown 3D structure
large nodes: some 3D structure is known or predicted
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCDHB10
protocadherin beta 10; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity) (800 aa)
Predicted Functional Partners:
ATP13A2
ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity (1180 aa)
0.418
MDH1B
malate dehydrogenase 1B, NAD (soluble) (518 aa)
0.406
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606 Other names: H. sapiens, Homo, Homo sapiens, human, man
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
ATP13A2
PCDHB10
ENSP00000327214
ENSP00000239446
ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity
protocadherin beta 10; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity)
0.418
MDH1B
PCDHB10
ENSP00000363533
ENSP00000239446
malate dehydrogenase 1B, NAD (soluble)
protocadherin beta 10; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity)
0.406
PCDHB10
ATP13A2
ENSP00000239446
ENSP00000327214
protocadherin beta 10; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity)
ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity
0.418
PCDHB10
MDH1B
ENSP00000239446
ENSP00000363533
protocadherin beta 10; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity)
Groups of genes that are frequently observed in each other's genomic neighborhood.
Databases
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Fusion
Genes that are sometimes fused into single open reading frames.
Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
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Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: