Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SLC25A2 | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2; Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix (301 aa) | ||||||||||||
Predicted Functional Partners:
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 | ASS1 | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) (412 aa) |
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0.958 | ||||||||
 | OTC | ornithine carbamoyltransferase (354 aa) |
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0.906 | ||||||||
 | ARG1 | arginase, liver (322 aa) |
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0.900 | ||||||||||
 | TAF7 | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa; Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively) (349 aa) |
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0.673 | ||||||||||
 | OAT | ornithine aminotransferase (439 aa) |
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0.624 | ||||||||||
 | ASL | argininosuccinate lyase (464 aa) |
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0.618 | |||||||||
 | ENSG00000249319 | Uncharacterized protein (293 aa) |
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0.516 | ||||||||||
 | PPM1N | protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) (430 aa) |
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0.507 | ||||||||||
 | ANKRD20A1 | ankyrin repeat domain 20 family, member A1 (823 aa) |
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0.477 | ||||||||||
 | LYVE1 | lymphatic vessel endothelial hyaluronan receptor 1; Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (322 aa) |
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0.474 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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