node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000259753 | ITGA11 | ENSP00000456711 | ENSP00000327290 | Integrin beta | integrin, alpha 11; Integrin alpha-11/beta-1 is a receptor for collagen | 0.856 |
ENSG00000259753 | ITGA2 | ENSP00000456711 | ENSP00000296585 | Integrin beta | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix | 0.860 |
ENSG00000259753 | ITGA3 | ENSP00000456711 | ENSP00000007722 | Integrin beta | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration | 0.878 |
ENSG00000259753 | ITGA4 | ENSP00000456711 | ENSP00000380227 | Integrin beta | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may [...] | 0.863 |
ENSG00000259753 | ITGA6 | ENSP00000456711 | ENSP00000386896 | Integrin beta | integrin, alpha 6 | 0.932 |
ENSG00000259753 | ITGA7 | ENSP00000456711 | ENSP00000452120 | Integrin beta | integrin, alpha 7 | 0.931 |
ENSG00000259753 | PTK2 | ENSP00000456711 | ENSP00000341189 | Integrin beta | PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] | 0.858 |
ENSG00000259753 | SDC1 | ENSP00000456711 | ENSP00000254351 | Integrin beta | syndecan 1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix | 0.810 |
ENSG00000259753 | TNN | ENSP00000456711 | ENSP00000239462 | Integrin beta | tenascin N; Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity) | 0.806 |
ITGA11 | ENSG00000259753 | ENSP00000327290 | ENSP00000456711 | integrin, alpha 11; Integrin alpha-11/beta-1 is a receptor for collagen | Integrin beta | 0.856 |
ITGA11 | ITGA2 | ENSP00000327290 | ENSP00000296585 | integrin, alpha 11; Integrin alpha-11/beta-1 is a receptor for collagen | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix | 0.744 |
ITGA11 | ITGA3 | ENSP00000327290 | ENSP00000007722 | integrin, alpha 11; Integrin alpha-11/beta-1 is a receptor for collagen | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration | 0.752 |
ITGA11 | ITGA4 | ENSP00000327290 | ENSP00000380227 | integrin, alpha 11; Integrin alpha-11/beta-1 is a receptor for collagen | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may [...] | 0.420 |
ITGA11 | ITGA6 | ENSP00000327290 | ENSP00000386896 | integrin, alpha 11; Integrin alpha-11/beta-1 is a receptor for collagen | integrin, alpha 6 | 0.419 |
ITGA11 | ITGA7 | ENSP00000327290 | ENSP00000452120 | integrin, alpha 11; Integrin alpha-11/beta-1 is a receptor for collagen | integrin, alpha 7 | 0.504 |
ITGA11 | ITGB1 | ENSP00000327290 | ENSP00000303351 | integrin, alpha 11; Integrin alpha-11/beta-1 is a receptor for collagen | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.969 |
ITGA11 | PTK2 | ENSP00000327290 | ENSP00000341189 | integrin, alpha 11; Integrin alpha-11/beta-1 is a receptor for collagen | PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] | 0.812 |
ITGA11 | TNN | ENSP00000327290 | ENSP00000239462 | integrin, alpha 11; Integrin alpha-11/beta-1 is a receptor for collagen | tenascin N; Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity) | 0.806 |
ITGA2 | ENSG00000259753 | ENSP00000296585 | ENSP00000456711 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix | Integrin beta | 0.860 |
ITGA2 | ITGA11 | ENSP00000296585 | ENSP00000327290 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix | integrin, alpha 11; Integrin alpha-11/beta-1 is a receptor for collagen | 0.744 |