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HOXC11 HOXC11 OG12 OG12 SHOX2 SHOX2 PITX1 PITX1 BMP4 BMP4 TBX4 TBX4 HOXC10 HOXC10 SHH SHH FGF10 FGF10 DHH DHH IHH IHH
"TBX4" - T-box 4 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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Score
TBX4T-box 4; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation (545 aa)    
Predicted Functional Partners:
FGF10
fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing (208 aa)
             score_image   0.930
SHH
sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] (462 aa)
         score_image   score_image   0.929
OG12
short stature homeobox protein 2 isoform c ; May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation (319 aa)
         score_image   score_image   0.907
SHOX2
short stature homeobox 2; May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation (355 aa)
         score_image   score_image   0.905
IHH
Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity) (411 aa)
         score_image   score_image   0.878
DHH
desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development (396 aa)
         score_image   score_image   0.862
PITX1
paired-like homeodomain 1; May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb (314 aa)
             score_image   0.760
HOXC10
homeobox C10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (342 aa)
             score_image   0.759
HOXC11
homeobox C11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene (304 aa)
             score_image   0.757
BMP4
bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) (408 aa)
         score_image   score_image   0.751
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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