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ULBP3 ULBP3 RAET1E RAET1E HCST HCST ULBP1 ULBP1 ULBP2 ULBP2 RAET1G RAET1G KLRK1 KLRK1 RAET1L RAET1L KLRF1 KLRF1 TYROBP TYROBP VAV1 VAV1
"KLRK1" - killer cell lectin-like receptor subfamily K, member 1 in Homo sapiens
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KLRK1killer cell lectin-like receptor subfamily K, member 1; Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes (216 aa)    
Predicted Functional Partners:
ULBP3
UL16 binding protein 3; Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1 (244 aa)
        score_image score_image score_image   0.999
HCST
hematopoietic cell signal transducer; Transmembrane adapter protein which associates with NKG2D to form an activation receptor NKG2D-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with NKG2D-DAP10 trigg [...] (93 aa)
        score_image score_image score_image   0.993
TYROBP
TYRO protein tyrosine kinase binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin (113 aa)
        score_image score_image score_image   0.964
ULBP2
UL16 binding protein 2; Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. [...] (246 aa)
        score_image score_image score_image   0.949
RAET1G
retinoic acid early transcript 1G; Acts as a ligand for the NKG2D receptor and mediates NK cell cytotoxicity via the receptor (334 aa)
        score_image score_image score_image   0.939
RAET1E
retinoic acid early transcript 1E; Ligand for the NKG2D receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes (263 aa)
          score_image score_image   0.926
ULBP1
UL16 binding protein 1; Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. [...] (244 aa)
          score_image score_image   0.905
RAET1L
retinoic acid early transcript 1L (246 aa)
          score_image score_image   0.859
KLRF1
killer cell lectin-like receptor subfamily F, member 1; Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts (232 aa)
            score_image   0.838
VAV1
vav 1 guanine nucleotide exchange factor; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation (845 aa)
            score_image   0.832
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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