node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANXA11 | TFG | ENSP00000265447 | ENSP00000240851 | annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis | TRK-fused gene | 0.755 |
ANXA11 | UBC | ENSP00000265447 | ENSP00000344818 | annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis | ubiquitin C | 0.897 |
EWSR1 | SEC24A | ENSP00000400142 | ENSP00000381823 | Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes | SEC24 family, member A (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex | 0.634 |
EWSR1 | TFG | ENSP00000400142 | ENSP00000240851 | Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes | TRK-fused gene | 0.719 |
EWSR1 | UBC | ENSP00000400142 | ENSP00000344818 | Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes | ubiquitin C | 0.929 |
FRS3 | NTRK1 | ENSP00000259748 | ENSP00000431418 | fibroblast growth factor receptor substrate 3; Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2 | neurotrophic tyrosine kinase, receptor, type 1 | 0.612 |
FRS3 | TFG | ENSP00000259748 | ENSP00000240851 | fibroblast growth factor receptor substrate 3; Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2 | TRK-fused gene | 0.817 |
MAPK1IP1L | TFG | ENSP00000378851 | ENSP00000240851 | mitogen-activated protein kinase 1 interacting protein 1-like | TRK-fused gene | 0.754 |
NTRK1 | FRS3 | ENSP00000431418 | ENSP00000259748 | neurotrophic tyrosine kinase, receptor, type 1 | fibroblast growth factor receptor substrate 3; Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2 | 0.612 |
NTRK1 | TFG | ENSP00000431418 | ENSP00000240851 | neurotrophic tyrosine kinase, receptor, type 1 | TRK-fused gene | 0.908 |
NTRK1 | TPR | ENSP00000431418 | ENSP00000356448 | neurotrophic tyrosine kinase, receptor, type 1 | translocated promoter region, nuclear basket protein; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates t [...] | 0.917 |
NTRK1 | UBC | ENSP00000431418 | ENSP00000344818 | neurotrophic tyrosine kinase, receptor, type 1 | ubiquitin C | 0.983 |
SEC24A | EWSR1 | ENSP00000381823 | ENSP00000400142 | SEC24 family, member A (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex | Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes | 0.634 |
SEC24A | TFG | ENSP00000381823 | ENSP00000240851 | SEC24 family, member A (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex | TRK-fused gene | 0.686 |
SEC24A | UBC | ENSP00000381823 | ENSP00000344818 | SEC24 family, member A (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex | ubiquitin C | 0.807 |
TFG | ANXA11 | ENSP00000240851 | ENSP00000265447 | TRK-fused gene | annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis | 0.755 |
TFG | EWSR1 | ENSP00000240851 | ENSP00000400142 | TRK-fused gene | Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes | 0.719 |
TFG | FRS3 | ENSP00000240851 | ENSP00000259748 | TRK-fused gene | fibroblast growth factor receptor substrate 3; Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2 | 0.817 |
TFG | MAPK1IP1L | ENSP00000240851 | ENSP00000378851 | TRK-fused gene | mitogen-activated protein kinase 1 interacting protein 1-like | 0.754 |
TFG | NTRK1 | ENSP00000240851 | ENSP00000431418 | TRK-fused gene | neurotrophic tyrosine kinase, receptor, type 1 | 0.908 |