node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BUD31 | CDC5L | ENSP00000222969 | ENSP00000360532 | BUD31 homolog (S. cerevisiae) | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.978 |
BUD31 | NAA50 | ENSP00000222969 | ENSP00000240922 | BUD31 homolog (S. cerevisiae) | N(alpha)-acetyltransferase 50, NatE catalytic subunit; Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity | 0.847 |
BUD31 | PRPF19 | ENSP00000222969 | ENSP00000227524 | BUD31 homolog (S. cerevisiae) | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] | 0.980 |
BUD31 | UBC | ENSP00000222969 | ENSP00000344818 | BUD31 homolog (S. cerevisiae) | ubiquitin C | 0.795 |
CDC5L | BUD31 | ENSP00000360532 | ENSP00000222969 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | BUD31 homolog (S. cerevisiae) | 0.978 |
CDC5L | NAA50 | ENSP00000360532 | ENSP00000240922 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | N(alpha)-acetyltransferase 50, NatE catalytic subunit; Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity | 0.942 |
CDC5L | PRPF19 | ENSP00000360532 | ENSP00000227524 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] | 0.999 |
CDC5L | UBC | ENSP00000360532 | ENSP00000344818 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | ubiquitin C | 0.740 |
HYPK | NAA15 | ENSP00000384474 | ENSP00000296543 | huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | N(alpha)-acetyltransferase 15, NatA auxiliary subunit; The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter | 0.967 |
HYPK | NAA16 | ENSP00000384474 | ENSP00000368716 | huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | N(alpha)-acetyltransferase 16, NatA auxiliary subunit; May belong to a complex displaying N-terminal acetyltransferase activity (By similarity) | 0.901 |
HYPK | NAA50 | ENSP00000384474 | ENSP00000240922 | huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | N(alpha)-acetyltransferase 50, NatE catalytic subunit; Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity | 0.899 |
HYPK | SMARCE1 | ENSP00000384474 | ENSP00000323967 | huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transitio [...] | 0.670 |
NAA15 | HYPK | ENSP00000296543 | ENSP00000384474 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit; The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter | huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | 0.967 |
NAA15 | NAA16 | ENSP00000296543 | ENSP00000368716 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit; The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter | N(alpha)-acetyltransferase 16, NatA auxiliary subunit; May belong to a complex displaying N-terminal acetyltransferase activity (By similarity) | 0.721 |
NAA15 | NAA35 | ENSP00000296543 | ENSP00000354972 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit; The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter | N(alpha)-acetyltransferase 35, NatC auxiliary subunit; Regulates proliferation of smooth muscle cells (By similarity). Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues | 0.958 |
NAA15 | NAA50 | ENSP00000296543 | ENSP00000240922 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit; The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter | N(alpha)-acetyltransferase 50, NatE catalytic subunit; Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity | 0.968 |
NAA15 | UBC | ENSP00000296543 | ENSP00000344818 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit; The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter | ubiquitin C | 0.942 |
NAA16 | HYPK | ENSP00000368716 | ENSP00000384474 | N(alpha)-acetyltransferase 16, NatA auxiliary subunit; May belong to a complex displaying N-terminal acetyltransferase activity (By similarity) | huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | 0.901 |
NAA16 | NAA15 | ENSP00000368716 | ENSP00000296543 | N(alpha)-acetyltransferase 16, NatA auxiliary subunit; May belong to a complex displaying N-terminal acetyltransferase activity (By similarity) | N(alpha)-acetyltransferase 15, NatA auxiliary subunit; The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter | 0.721 |
NAA16 | NAA35 | ENSP00000368716 | ENSP00000354972 | N(alpha)-acetyltransferase 16, NatA auxiliary subunit; May belong to a complex displaying N-terminal acetyltransferase activity (By similarity) | N(alpha)-acetyltransferase 35, NatC auxiliary subunit; Regulates proliferation of smooth muscle cells (By similarity). Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues | 0.833 |