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STRINGSTRING
PEX10 PEX10 H326 H326 PEX12 PEX12 PEX2 PEX2 PEX5 PEX5 PEX14 PEX14 PEX13 PEX13 PEX19 PEX19 PEX3 PEX3 PEX16 PEX16 PEX6 PEX6
"PEX16" - peroxisomal biogenesis factor 16 in Homo sapiens
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PEX16peroxisomal biogenesis factor 16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (346 aa)    
Predicted Functional Partners:
PEX19
peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (299 aa)
        score_image   score_image   0.997
PEX3
peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes (373 aa)
        score_image   score_image   0.951
PEX14
peroxisomal biogenesis factor 14; Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17 (377 aa)
        score_image   score_image   0.891
H326
DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (751 aa)
            score_image   0.863
PEX10
peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes (346 aa)
            score_image   0.859
PEX2
peroxisomal biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes (305 aa)
            score_image   0.841
PEX5
peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import (654 aa)
            score_image   0.787
PEX6
peroxisomal biogenesis factor 6; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (980 aa)
            score_image   0.786
PEX12
peroxisomal biogenesis factor 12; Required for protein import into peroxisomes (359 aa)
            score_image   0.773
PEX13
peroxisomal biogenesis factor 13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (403 aa)
            score_image   0.754
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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