| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DEPDC7 | ECT2 | ENSP00000241051 | ENSP00000232458 | DEP domain containing 7 | epithelial cell transforming sequence 2 oncogene; Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to t [...] | 0.905 |
| DEPDC7 | FGD3 | ENSP00000241051 | ENSP00000336914 | DEP domain containing 7 | FYVE, RhoGEF and PH domain containing 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity) | 0.901 |
| DEPDC7 | MCF2 | ENSP00000241051 | ENSP00000430276 | DEP domain containing 7 | MCF.2 cell line derived transforming sequence | 0.900 |
| DEPDC7 | MCF2L | ENSP00000241051 | ENSP00000440374 | DEP domain containing 7 | MCF.2 cell line derived transforming sequence-like | 0.900 |
| DEPDC7 | OBSCN | ENSP00000241051 | ENSP00000455507 | DEP domain containing 7 | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.900 |
| DEPDC7 | RHOA | ENSP00000241051 | ENSP00000400175 | DEP domain containing 7 | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.900 |
| DEPDC7 | RHOBTB2 | ENSP00000241051 | ENSP00000427926 | DEP domain containing 7 | Rho-related BTB domain containing 2 | 0.900 |
| DEPDC7 | VAV1 | ENSP00000241051 | ENSP00000472929 | DEP domain containing 7 | vav 1 guanine nucleotide exchange factor; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation | 0.900 |
| DEPDC7 | VAV2 | ENSP00000241051 | ENSP00000360916 | DEP domain containing 7 | vav 2 guanine nucleotide exchange factor | 0.907 |
| DEPDC7 | VAV3 | ENSP00000241051 | ENSP00000359073 | DEP domain containing 7 | vav 3 guanine nucleotide exchange factor | 0.905 |
| ECT2 | DEPDC7 | ENSP00000232458 | ENSP00000241051 | epithelial cell transforming sequence 2 oncogene; Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to t [...] | DEP domain containing 7 | 0.905 |
| ECT2 | MCF2 | ENSP00000232458 | ENSP00000430276 | epithelial cell transforming sequence 2 oncogene; Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to t [...] | MCF.2 cell line derived transforming sequence | 0.605 |
| ECT2 | RHOA | ENSP00000232458 | ENSP00000400175 | epithelial cell transforming sequence 2 oncogene; Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to t [...] | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.986 |
| ECT2 | RHOBTB2 | ENSP00000232458 | ENSP00000427926 | epithelial cell transforming sequence 2 oncogene; Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to t [...] | Rho-related BTB domain containing 2 | 0.921 |
| FGD3 | DEPDC7 | ENSP00000336914 | ENSP00000241051 | FYVE, RhoGEF and PH domain containing 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity) | DEP domain containing 7 | 0.901 |
| FGD3 | RHOA | ENSP00000336914 | ENSP00000400175 | FYVE, RhoGEF and PH domain containing 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity) | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.909 |
| FGD3 | RHOBTB2 | ENSP00000336914 | ENSP00000427926 | FYVE, RhoGEF and PH domain containing 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity) | Rho-related BTB domain containing 2 | 0.900 |
| MCF2 | DEPDC7 | ENSP00000430276 | ENSP00000241051 | MCF.2 cell line derived transforming sequence | DEP domain containing 7 | 0.900 |
| MCF2 | ECT2 | ENSP00000430276 | ENSP00000232458 | MCF.2 cell line derived transforming sequence | epithelial cell transforming sequence 2 oncogene; Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to t [...] | 0.605 |
| MCF2 | RHOA | ENSP00000430276 | ENSP00000400175 | MCF.2 cell line derived transforming sequence | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.991 |
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