node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKMY1 | GAL3ST2 | ENSP00000272972 | ENSP00000192314 | ankyrin repeat and MYND domain containing 1 | galactose-3-O-sulfotransferase 2; Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal- beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency | 0.505 |
ANKMY1 | MTERFD2 | ENSP00000272972 | ENSP00000241527 | ankyrin repeat and MYND domain containing 1 | MTERF domain containing 2; Required for the targeting of the methyltransferase NSUN4 to mitochondrial large ribosomal subunit and efficient rRNA methylation | 0.459 |
FTSJ2 | MTERF | ENSP00000242257 | ENSP00000248643 | FtsJ RNA methyltransferase homolog 2 (E. coli); Probable methyltransferase | mitochondrial transcription termination factor; Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Probably requires one or more components for termination activity | 0.506 |
FTSJ2 | MTERFD2 | ENSP00000242257 | ENSP00000241527 | FtsJ RNA methyltransferase homolog 2 (E. coli); Probable methyltransferase | MTERF domain containing 2; Required for the targeting of the methyltransferase NSUN4 to mitochondrial large ribosomal subunit and efficient rRNA methylation | 0.502 |
FTSJ2 | MTERFD3 | ENSP00000242257 | ENSP00000240050 | FtsJ RNA methyltransferase homolog 2 (E. coli); Probable methyltransferase | MTERF domain containing 3; Binds promoter DNA and regulates mitochondrial transcription. Required for normal levels of transcription, both for mRNA and tRNA. Required for normal mitochondrial protein synthesis, assembly of respiratory complexes and normal mitochondrial function (By similarity) | 0.540 |
FTSJ2 | NSUN4 | ENSP00000242257 | ENSP00000419740 | FtsJ RNA methyltransferase homolog 2 (E. coli); Probable methyltransferase | NOP2/Sun domain family, member 4; Involved in mitochondrial ribosome large subunit biogenesis | 0.734 |
FTSJ2 | NSUN5 | ENSP00000242257 | ENSP00000309126 | FtsJ RNA methyltransferase homolog 2 (E. coli); Probable methyltransferase | NOP2/Sun domain family, member 5 | 0.603 |
FTSJ2 | TFB1M | ENSP00000242257 | ENSP00000356134 | FtsJ RNA methyltransferase homolog 2 (E. coli); Probable methyltransferase | transcription factor B1, mitochondrial; S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity | 0.917 |
FTSJ2 | UBC | ENSP00000242257 | ENSP00000344818 | FtsJ RNA methyltransferase homolog 2 (E. coli); Probable methyltransferase | ubiquitin C | 0.640 |
GAL3ST2 | ANKMY1 | ENSP00000192314 | ENSP00000272972 | galactose-3-O-sulfotransferase 2; Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal- beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency | ankyrin repeat and MYND domain containing 1 | 0.505 |
GAL3ST2 | MTERFD2 | ENSP00000192314 | ENSP00000241527 | galactose-3-O-sulfotransferase 2; Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal- beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency | MTERF domain containing 2; Required for the targeting of the methyltransferase NSUN4 to mitochondrial large ribosomal subunit and efficient rRNA methylation | 0.535 |
MALSU1 | MTERFD2 | ENSP00000419370 | ENSP00000241527 | mitochondrial assembly of ribosomal large subunit 1; May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome | MTERF domain containing 2; Required for the targeting of the methyltransferase NSUN4 to mitochondrial large ribosomal subunit and efficient rRNA methylation | 0.511 |
MALSU1 | UBC | ENSP00000419370 | ENSP00000344818 | mitochondrial assembly of ribosomal large subunit 1; May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome | ubiquitin C | 0.483 |
MTERF | FTSJ2 | ENSP00000248643 | ENSP00000242257 | mitochondrial transcription termination factor; Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Probably requires one or more components for termination activity | FtsJ RNA methyltransferase homolog 2 (E. coli); Probable methyltransferase | 0.506 |
MTERF | MTERFD2 | ENSP00000248643 | ENSP00000241527 | mitochondrial transcription termination factor; Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Probably requires one or more components for termination activity | MTERF domain containing 2; Required for the targeting of the methyltransferase NSUN4 to mitochondrial large ribosomal subunit and efficient rRNA methylation | 0.648 |
MTERF | NSUN4 | ENSP00000248643 | ENSP00000419740 | mitochondrial transcription termination factor; Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Probably requires one or more components for termination activity | NOP2/Sun domain family, member 4; Involved in mitochondrial ribosome large subunit biogenesis | 0.472 |
MTERF | TFB1M | ENSP00000248643 | ENSP00000356134 | mitochondrial transcription termination factor; Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Probably requires one or more components for termination activity | transcription factor B1, mitochondrial; S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity | 0.778 |
MTERFD2 | ANKMY1 | ENSP00000241527 | ENSP00000272972 | MTERF domain containing 2; Required for the targeting of the methyltransferase NSUN4 to mitochondrial large ribosomal subunit and efficient rRNA methylation | ankyrin repeat and MYND domain containing 1 | 0.459 |
MTERFD2 | FTSJ2 | ENSP00000241527 | ENSP00000242257 | MTERF domain containing 2; Required for the targeting of the methyltransferase NSUN4 to mitochondrial large ribosomal subunit and efficient rRNA methylation | FtsJ RNA methyltransferase homolog 2 (E. coli); Probable methyltransferase | 0.502 |
MTERFD2 | GAL3ST2 | ENSP00000241527 | ENSP00000192314 | MTERF domain containing 2; Required for the targeting of the methyltransferase NSUN4 to mitochondrial large ribosomal subunit and efficient rRNA methylation | galactose-3-O-sulfotransferase 2; Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal- beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency | 0.535 |