| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1GALT1C1 | PRM1 | ENSP00000304364 | ENSP00000310515 | C1GALT1-specific chaperone 1; Probable chaperone required for the generation of 1 O- glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) | protamine 1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | 0.681 |
| C1GALT1C1 | PRM2 | ENSP00000304364 | ENSP00000241808 | C1GALT1-specific chaperone 1; Probable chaperone required for the generation of 1 O- glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) | protamine 2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex | 0.607 |
| C1GALT1C1 | TNP1 | ENSP00000304364 | ENSP00000236979 | C1GALT1-specific chaperone 1; Probable chaperone required for the generation of 1 O- glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) | transition protein 1 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins | 0.562 |
| C1GALT1C1 | TNP2 | ENSP00000304364 | ENSP00000325738 | C1GALT1-specific chaperone 1; Probable chaperone required for the generation of 1 O- glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) | transition protein 2 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (By similarity) | 0.610 |
| CAMK4 | PRM1 | ENSP00000282356 | ENSP00000310515 | calcium/calmodulin-dependent protein kinase IV; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of [...] | protamine 1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | 0.480 |
| CAMK4 | PRM2 | ENSP00000282356 | ENSP00000241808 | calcium/calmodulin-dependent protein kinase IV; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of [...] | protamine 2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex | 0.897 |
| CAMK4 | TNP2 | ENSP00000282356 | ENSP00000325738 | calcium/calmodulin-dependent protein kinase IV; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of [...] | transition protein 2 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (By similarity) | 0.487 |
| HIST1H1T | PGK2 | ENSP00000341214 | ENSP00000305995 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | phosphoglycerate kinase 2 | 0.562 |
| HIST1H1T | PRM1 | ENSP00000341214 | ENSP00000310515 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | protamine 1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | 0.637 |
| HIST1H1T | PRM2 | ENSP00000341214 | ENSP00000241808 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | protamine 2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex | 0.633 |
| HIST1H1T | TNP1 | ENSP00000341214 | ENSP00000236979 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | transition protein 1 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins | 0.700 |
| HIST1H1T | TNP2 | ENSP00000341214 | ENSP00000325738 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | transition protein 2 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (By similarity) | 0.645 |
| KDM3A | PRM1 | ENSP00000323659 | ENSP00000310515 | lysine (K)-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activa [...] | protamine 1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | 0.817 |
| KDM3A | PRM2 | ENSP00000323659 | ENSP00000241808 | lysine (K)-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activa [...] | protamine 2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex | 0.607 |
| KDM3A | TNP1 | ENSP00000323659 | ENSP00000236979 | lysine (K)-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activa [...] | transition protein 1 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins | 0.753 |
| KDM3A | TNP2 | ENSP00000323659 | ENSP00000325738 | lysine (K)-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activa [...] | transition protein 2 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (By similarity) | 0.610 |
| KLHL10 | PRM1 | ENSP00000293303 | ENSP00000310515 | kelch-like 10 (Drosophila) | protamine 1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | 0.812 |
| KLHL10 | PRM2 | ENSP00000293303 | ENSP00000241808 | kelch-like 10 (Drosophila) | protamine 2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex | 0.754 |
| PGK2 | HIST1H1T | ENSP00000305995 | ENSP00000341214 | phosphoglycerate kinase 2 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | 0.562 |
| PGK2 | PRM1 | ENSP00000305995 | ENSP00000310515 | phosphoglycerate kinase 2 | protamine 1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | 0.725 |
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